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Functional roles for the striatal-enriched transcription factor, bcl11b, in the control of striatal gene expression and transcriptional dysregulation in huntington's disease

Academic Article
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Overview

authors

  • Desplats, P. A.
  • Lambert, J. R.
  • Thomas, Elizabeth

publication date

  • September 2008

journal

  • Neurobiology of Disease  Journal

abstract

  • Transcriptional dysregulation has emerged as a central pathogenic mechanism in Huntington's disease (HD), which is associated with neuropathological changes predominantly in the striatum. Here we demonstrate that expression of Bcl11b (a.k.a. CTIP2), a transcription factor exhibiting highly-enriched localization in adult striatum, is significantly decreased in HD cells, mouse models and human subjects and that overexpression of Bcl11b attenuates toxic effects of mutant huntingtin in cultured striatal neurons. We show that Bcl11b directly activates the proximal promoter regions of striatal-enriched genes and can increase mRNA levels of striatal-expressing genes. We further demonstrate an interaction between Bcl11b and huntingtin protein in cultured cells and brain homogenates from HD R6/1 and YAC72 transgenic mice. We propose that sequestration and/or decreased expression of Bcl11b in HD is responsible, at least in part, for the dysregulation of striatal gene expression observed in HD and may contribute to the specificity of pathology observed in this disease.

subject areas

  • Animals
  • Binding Sites
  • Cell Differentiation
  • Cell Line, Transformed
  • Corpus Striatum
  • DNA-Binding Proteins
  • Down-Regulation
  • Female
  • Gene Expression Regulation
  • Humans
  • Huntington Disease
  • Male
  • Mice
  • Mice, Transgenic
  • Middle Aged
  • Nerve Tissue Proteins
  • Nuclear Proteins
  • Phenotype
  • Promoter Regions, Genetic
  • RNA, Messenger
  • Repressor Proteins
  • Transcription Factors
  • Transcription, Genetic
  • Transcriptional Activation
  • Tumor Suppressor Proteins
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Research

keywords

  • Huntington's disease
  • gene expression
  • interaction
  • promoter
  • specificity
  • striatum
  • transcription factor
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Identity

PubMed Central ID

  • PMC2569875

International Standard Serial Number (ISSN)

  • 0969-9961

Digital Object Identifier (DOI)

  • 10.1016/j.nbd.2008.05.005

PubMed ID

  • 18595722
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Additional Document Info

start page

  • 298

end page

  • 308

volume

  • 31

issue

  • 3

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