Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

Mir-290-295 deficiency in mice results in partially penetrant embryonic lethality and germ cell defects

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Medeiros, L. A.
  • Dennis, L. M.
  • Gill, Matt
  • Houbaviy, H.
  • Markoulaki, S.
  • Fu, D. D.
  • White, A. C.
  • Kirak, Oktay
  • Sharp, P. A.
  • Page, D. C.
  • Jaenisch, R.

publication date

  • August 2011

journal

  • Proceedings of the National Academy of Sciences of the United States of America  Journal

abstract

  • Mir-290 through mir-295 (mir-290-295) is a mammalian-specific microRNA (miRNA) cluster that, in mice, is expressed specifically in early embryos and embryonic germ cells. Here, we show that mir-290-295 plays important roles in embryonic development as indicated by the partially penetrant lethality of mutant embryos. In addition, we show that in surviving mir-290-295-deficient embryos, female but not male fertility is compromised. This impairment in fertility arises from a defect in migrating primordial germ cells and occurs equally in male and female mutant animals. Male mir-290-295(-/-) mice, due to the extended proliferative lifespan of their germ cells, are able to recover from this initial germ cell loss and are fertile. Female mir-290-295(-/-) mice are unable to recover and are sterile, due to premature ovarian failure.

subject areas

  • Aging
  • Animals
  • Animals, Newborn
  • Apoptosis
  • Cell Count
  • Cell Cycle
  • Embryo Loss
  • Embryo, Mammalian
  • Female
  • Fertility
  • Gene Expression Regulation, Developmental
  • Germ Cells
  • Gonads
  • Infertility, Female
  • Male
  • Mice
  • Mice, Mutant Strains
  • MicroRNAs
  • Penetrance
scroll to property group menus

Identity

PubMed Central ID

  • PMC3161528

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.1111241108

PubMed ID

  • 21844366
scroll to property group menus

Additional Document Info

start page

  • 14163

end page

  • 14168

volume

  • 108

issue

  • 34

©2021 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support