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Oncogenic transformation by jun: Role of transactivation and homodimerization

Academic Article
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Overview

authors

  • Hartl, M.
  • Vogt, Peter K.

publication date

  • December 1992

journal

  • Cell Growth & Differentiation  Journal

abstract

  • Jun/JunD and Jun/GCN4 chimeras transform chicken embryo fibroblasts and activate the collagenase promoter in these same cells. Individual constructs differ widely in the two activities, and there is no correlation between transformation and transactivation. These results suggest that oncogenic transformation by Jun is not caused merely by an upregulation of AP-1 activity. Jun constructs with a modified dimerization domain allowing only homodimerization are active in transformation and transactivation in chicken embryo fibroblast cultures. Homodimers of Jun therefore transform and transactivate.

subject areas

  • Animals
  • Biopolymers
  • Cell Transformation, Neoplastic
  • Chick Embryo
  • Fibroblasts
  • Genetic Vectors
  • Mutation
  • Protein Structure, Tertiary
  • Proto-Oncogene Proteins c-jun
  • Recombinant Proteins
  • Transcription, Genetic
  • Transcriptional Activation
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Identity

International Standard Serial Number (ISSN)

  • 1044-9523

PubMed ID

  • 1472470
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Additional Document Info

start page

  • 899

end page

  • 908

volume

  • 3

issue

  • 12

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