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Interaction of factor VIII antigen in hemophilic plasmas with human antibodies to factor VIII

Academic Article
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Overview

authors

  • Zimmerman, T. S.
  • Delapointe, L.
  • Edgington, Thomas

publication date

  • 1977

journal

  • Journal of Clinical Investigation  Journal

abstract

  • By utilizing a simple modification of previous immunological assays, we have demonstrated that most, if not all, hemophilic plasmas contain antigen reactive with human antibodies directed against Factor VIII procoagulant activity (VIIIc). Antibodies developing in a nonhemophiliac patient and in a hemophiliac patient gave similar results. The VIIIc antigen so identified was removed from hemophilic plasmas with immobilized rabbit antibody which reacted with normal VIIIc and von Willebrand's disease antigen. These data suggest that there are greater antigenic similarities between normal and hemophilic Factor VIII than previously thought.

subject areas

  • Antigen-Antibody Reactions
  • Factor VIII
  • Hemophilia A
  • Humans
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Identity

PubMed Central ID

  • PMC372307

International Standard Serial Number (ISSN)

  • 0021-9738

Digital Object Identifier (DOI)

  • 10.1172/jci108721

PubMed ID

  • 853128
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Additional Document Info

start page

  • 984

end page

  • 989

volume

  • 59

issue

  • 5

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