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Schleim, K. D.

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    • Palyha, O. C., Feighner, S. D., Tan, C. P., McKee, K. K., Hreniuk, D. L., Gao, Y. D., Schleim, K. D., Yang, L. H., Morriello, G. J., Nargund, R., Patchett, A. A., Howard, A. D., et al. Ligand activation domain of human orphan growth hormone (GH) secretagogue receptor (GHS-R) conserved from Pufferfish to humans Molecular Endocrinology  2000 14:160-169  DOI:10.1210/me.14.1.160  PMID:10628755
    • Yang, L. H., Morriello, G., Leung, K., Jacks, T., Cheng, K., Schleim, K. D., Smith, R., Patchett, A. A. Thiazole-derived potent, highly bioavailable short duration growth hormone secretagogues Bioorganic & Medicinal Chemistry Letters  1999 9:1761-1766  DOI:10.1016/S0960-894X(99)00286-3  PMID:10406638
    • Schleim, K. D., Jacks, T., Cunningham, P., Feeney, W., Frazier, E. G., Niebauer, G. W., Zhang, D., Chen, H., Smith, R. G., Hickey, G. Increases in circulating insulin-like growth factor I levels by the oral growth hormone secretagogue MK-0677 in the beagle are dependent upon pituitary mediation Endocrinology  1999 140:1552-1558  DOI:10.1210/en.140.4.1552  PMID:10098487
    • Yang, L. H., Morriello, G., Patchett, A. A., Leung, K., Jacks, T., Cheng, K., Schleim, K. D., Feeney, W., Chan, W. W. S., Chiu, S. H. L., Smith, R. G. 1-[2(R)-(2-amino-2-methylpropionylamino)-3-(1H-indol-3-yl)propionyl]- 3-benzylpiperidine-3(S)-carboxylic acid ethyl ester (L-163,540): a potent, orally bioavailable, and short-duration growth hormone secretagogue Journal of Medicinal Chemistry  1998 41:2439-2441  DOI:10.1021/jm9800191  PMID:9651148
    • Barakat, K. J., Cheng, K., Chan, W. W. S., Butler, B. S., Jacks, T. M., Schleim, K. D., Hora, D. F., Hickey, G. J., Smith, R. G., Patchett, A. A., Nargund, R. P. Synthesis and biological activities of phenyl piperazine-based peptidomimetic growth hormone secretagogues Bioorganic & Medicinal Chemistry Letters  1998 8:1431-1436  DOI:10.1016/s0960-894x(98)00238-8  PMID:9871779
    • DeVita, R. J., Bochis, R., Frontier, A. J., Kotliar, A., Fisher, M. H., Schoen, W. R., Wyvratt, M. J., Cheng, K., Chan, W. W. S., Butler, B., Jacks, T. M., Hickey, G. J., et al. A potent, orally bioavailable benzazepinone growth hormone secretagogue Journal of Medicinal Chemistry  1998 41:1716-1728  DOI:10.1021/jm970816j  PMID:9572898
    • Yang, L. H., Morriello, G., Prendergast, K., Cheng, K., Jacks, T., Chan, W. W. S., Schleim, K. D., Smith, R. G., Patchett, A. A. Potent 3-spiropiperidine growth hormone secretagogues Bioorganic & Medicinal Chemistry Letters  1998 8:107-112  DOI:10.1016/s0960-894x(97)10199-8  PMID:9925440
    • Tata, J. R., Lu, Z. J., Jacks, T. M., Schleim, K. D., Cheng, K., Wei, L. T., Chan, W. W. S., Butler, B., Tsou, N., Leung, K., Chiu, S. H. L., Hickey, G., et al. The design and synthesis of orally active short duration spiroindane growth hormone secretagogues Bioorganic & Medicinal Chemistry Letters  1997 7:2319-2324  DOI:10.1016/s0960-894x(97)00421-6
    • Hickey, G. J., Jacks, T. M., Schleim, K. D., Frazier, E., Chen, H. Y., Krupa, D., Feeney, W., Nargund, R. P., Patchett, A. A., Smith, R. G. Repeat administration of the GH secretagogue MK-0677 increases and maintains elevated IGF-I levels in beagles Journal of Endocrinology  1997 152:183-192  DOI:10.1677/joe.0.1520183  PMID:9071975

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