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Age-related effects of Ginkgo biloba extract on synaptic plasticity and excitability

Academic Article
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Overview

authors

  • Williams, B.
  • Watanabe, C. M. H.
  • Schultz, Peter
  • Rimbach, G.
  • Krucker, T.

publication date

  • August 2004

journal

  • Neurobiology of Aging  Journal

abstract

  • EGb 761 is a standardized extract from the Ginkgo biloba leaf and is purported to improve age-related memory impairment. The acute and chronic effect of EGb 761 on synaptic transmission and plasticity in hippocampal slices from young adult (8-12 weeks) and aged (18-24 months) C57Bl/6 mice was tested because hippocampal plasticity is believed to be a key component of memory. Acutely applied EGb 761 significantly increased neuronal excitability in slices from aged mice by reducing the population spike threshold and increased the early phase of long-term potentiation, though there was no effect in slices from young adults. In chronically treated mice fed for 30 days with an EGb 761-supplemented diet, EGb 761 significantly increased the population spike threshold and long-term potentiation in slices from aged animals, but had no effect on slices from young adults. The rapid effects of EGb 761 on plasticity indicate a direct interaction with the glutamatergic system and raise interesting implications with respect to a mechanism explaining its effect on cognitive enhancement in human subjects experiencing dementia.

subject areas

  • Aging
  • Animals
  • Ginkgo biloba
  • Hippocampus
  • In Vitro Techniques
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Neuronal Plasticity
  • Plant Extracts
  • Synaptic Transmission
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Research

keywords

  • EGb 761
  • Ginkgo
  • acute
  • cognition enhancer
  • cognitive enhancement
  • dietary
  • learning and memory
  • long-term potentiation
  • paired-pulse facilitation
  • plasticity
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Identity

International Standard Serial Number (ISSN)

  • 0197-4580

Digital Object Identifier (DOI)

  • 10.1016/j.neurobiolaging.2003.10.008

PubMed ID

  • 15212849
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Additional Document Info

start page

  • 955

end page

  • 962

volume

  • 25

issue

  • 7

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