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B lymphocyte-restricted expression of prion protein does not enable prion replication in prion protein knockout mice

Academic Article
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Overview

authors

  • Montrasio, F.
  • Cozzio, A.
  • Flechsig, E.
  • Rossi, D.
  • Klein, M. A.
  • Rulicke, T.
  • Raeber, A. J.
  • Vosshenrich, C. A. J.
  • Proft, J.
  • Aguzzi, A.
  • Weissmann, Charles

publication date

  • March 2001

journal

  • Proceedings of the National Academy of Sciences of the United States of America  Journal

abstract

  • Prion replication in spleen and neuroinvasion after i.p. inoculation of mice is impaired in forms of immunodeficiency where mature B lymphocytes are lacking. In spleens of wild-type mice, infectivity is associated with B and T lymphocytes and stroma but not with circulating lymphocytes. We generated transgenic prion protein knockout mice overexpressing prion protein in B lymphocytes and found that they failed to accumulate prions in spleen after i.p. inoculation. We conclude that splenic B lymphocytes are not prion-replication competent and that they acquire prions from other cells, most likely follicular dendritic cells with which they closely associate and whose maturation depends on them.

subject areas

  • Animals
  • B-Lymphocytes
  • Central Nervous System
  • Dendritic Cells, Follicular
  • Mice
  • Mice, Knockout
  • Mice, Transgenic
  • Prions
  • Spleen
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Identity

PubMed Central ID

  • PMC31174

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.051609398

PubMed ID

  • 11274428
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Additional Document Info

start page

  • 4034

end page

  • 4037

volume

  • 98

issue

  • 7

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