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Control of b cell production by the adaptor protein lnk: Definition of a conserved family of signal-modulating proteins

Academic Article
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Overview

authors

  • Takaki, S.
  • Sauer, Karsten
  • Iritani, B. M.
  • Chien, S.
  • Ebihara, Y.
  • Tsuji, K.
  • Takatsu, K.
  • Perlmutter, R. M.

publication date

  • November 2000

journal

  • Immunity  Journal

abstract

  • Lnk is an SH2 domain-containing adaptor protein expressed preferentially in lymphocytes. To illuminate the importance of Lnk, we generated lnk(-/-) mice. Whereas T cell development was unaffected, pre-B and immature B cells accumulated in the spleens. In the bone marrow, B-lineage cells were proportionately increased, reflecting enhanced production of pro-B cells that resulted in part from hypersensitivity of precursors to SCF, the ligand for c-kit. Hence, Lnk ordinarily acts to regulate B cell production. Further characterization of lnk(-/-) mice also revealed that full-length Lnk is a 68 kDa protein containing a conserved proline-rich region and a PH domain. Lnk is a representative of a multigene adaptor protein family whose members act, by analogy with Lnk, to modulate intracellular signaling.

subject areas

  • Amino Acid Sequence
  • Animals
  • B-Lymphocytes
  • Cell Differentiation
  • Gene Expression Regulation, Developmental
  • Intracellular Signaling Peptides and Proteins
  • Mice
  • Mice, Knockout
  • Molecular Sequence Data
  • Proteins
  • Sequence Alignment
  • Signal Transduction
  • src Homology Domains
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Identity

International Standard Serial Number (ISSN)

  • 1074-7613

Digital Object Identifier (DOI)

  • 10.1016/s1074-7613(00)00060-1

PubMed ID

  • 11114373
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Additional Document Info

start page

  • 599

end page

  • 609

volume

  • 13

issue

  • 5

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