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Inhibition of gonadotropin by delta9-tetrahydrocannabinol: mediation by steroid receptors?

Academic Article
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Overview

authors

  • Smith, Roy
  • Besch, N. F.
  • Besch, P. K.
  • Smith, C. G.

publication date

  • 1979

journal

  • Science  Journal

abstract

  • Competition assays for estradiol receptors in cytosol preparations of uteri from rhesus monkeys and humans showed that delta9-tetrahydrocannabinol (THC) does not compete with estradiol for intracellular estrogen recptors. Although isotopically labeled THC bound to macromolecules in uterine cytosol from the rhesus monkey, the binding was not displaced by unlabeled THC, diethylstilbestrol, estradiol, progesterone, cortisol, or 5 alpha-dihydrostestosterone. Scatchard analyses indicated that high-affinity saturable binding of THC to cytosol did not occur. Thus the inhibitory effect of THC on gonadotropin and steroid secretion in primates is not mediated by the interaction of THC with intracellular steroid hormone receptors.

subject areas

  • Animals
  • Binding, Competitive
  • Cytosol
  • Diethylstilbestrol
  • Dronabinol
  • Estradiol
  • Female
  • Haplorhini
  • Humans
  • Receptors, Estrogen
  • Steroids
  • Uterus
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Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.107589

PubMed ID

  • 107589
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Additional Document Info

start page

  • 325

end page

  • 327

volume

  • 204

issue

  • 4390

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