articles
- A small molecule drug conjugate (SMDC) of DUPA and a duocarmycin built on the solid phase. 10:2170-2174. 2019
- Synthesis and evaluation of 6-heteroarylamino-2,4,5-trimethylpyridin-3-ols as inhibitors of TNF-α-induced cell adhesion and inflammatory bowel disease. 9:1305-1310. 2018
- The semi-synthesis, biological evaluation and docking analysis of the oxime, hydrazine and hydrazide derivatives of platensimycin. 9:789-794. 2018
- A structurally guided dissection-then-evolution strategy for ligand optimization of smoothened receptor. 8:1332-1336. 2017
- Discovery of cyclopropyl chromane-derived pyridopyrazine-1,6-dione γ- secretase modulators with robust central efficacy. 8:730-743. 2017
- Identification of imidazo 1,2-b pyridazine TYK2 pseudokinase ligands as potent and selective allosteric inhibitors of TYK2 signalling. 8:700-712. 2017
- Exploiting the co-reliance of tumours upon transport of amino acids and lactate: Gln and Tyr conjugates of MCT1 inhibitors. 7:900-905. 2016
- Screening for covalent inhibitors using DNA-display of small molecule libraries functionalized with cysteine reactive moieties. 7:1340-1351. 2016
- Design, synthesis, and biological activity of N-alkylated analogue of NCL1, a selective inhibitor of lysine-specific demethylase 1. 6:407-412. 2015
- Elucidation of the shanorellin biosynthetic pathway and functional analysis of associated enzymes. 6:425-430. 2015
- Substituted 4-hydroxy-1,2,3-triazoles: synthesis, characterization and first drug design applications through bioisosteric modulation and scaffold hopping approaches. 6:1285-1292. 2015
- Optimizing glucokinase activator binding kinetics to lower in vivo hypoglycemia risk. 5:802-807. 2014
- Development of CBAP-BPyne, a probe for γ-secretase and presenilinase. 5:338-341. 2014
- Discovery of selective 2,4-diaminopyrimidine-based photoaffinity probes for glyoxalase I. 5:352-357. 2014
- Investigating γ-secretase protein interactions in live cells using active site-directed clickable dual-photoaffinity probes. 5:321-327. 2014
- Polyhydroxylated pyrrolidine and 2-oxapyrrolizidine as glycosidase inhibitors. 4:783-791. 2013
- Synthetic modulators of the retinoic acid receptor-related orphan receptors. 4:764-776. 2013
- Synthesis of 1,4-triazole linked zanamivir dimers as highly potent inhibitors of influenza A and B. 4:383-386. 2013
- Latent antibiotics and the potential of the arylomycins for broad-spectrum antibacterial activity. 3:916-925. 2012
- Sangamides, a new class of cyclophilin-inhibiting host-targeted antivirals for treatment of hcv infection. 3:938-943. 2012
- Synthesis and SAR of 2,4-diaminopyrimidines as potent c-jun n-terminal kinase inhibitors. 3:238-243. 2012
- Discovery of GS-8374, a potent human immunodeficiency virus type 1 protease inhibitor with a superior resistance profile. 2:1093-1098. 2011
- Designing glucokinase activators with reduced hypoglycemia risk: discovery of N,N-dimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)-carbamoyl)benzofuran- 4-yloxy)pyrimidine-2-carboxamide as a clinical candidate for the treatment of type 2 diabetes mellitus. 2:828-839. 2011
- Asymmetric synthesis of potent chroman-based Rho kinase (ROCK-II) inhibitors. 2:73-75. 2011