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Galanin: a neuropeptide with inhibitory actions

Academic Article
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Overview

authors

  • Kask, K.
  • Langel, Ülo
  • Bartfai, Tamas

publication date

  • December 1995

journal

  • Cellular and Molecular Neurobiology  Journal

abstract

  • 1. Galanin is a 29 (in humans 30) amino acids long neuropeptide with mostly inhibitory, hyperpolarizing actions. 2. Differential structural requirements of truncated forms of galanin and differential agonist/antagonist behaviour of chimeric peptides, high affinity galanin receptor ligands suggest the presence of pharmacologically distinct galanin receptor subtypes. 3. The galanin receptor from human Bowes melanoma cell line--a member of G-protein coupled receptor superfamily--has been cloned. 4. Galanin acts via Gi/G(o) proteins inhibiting cAMP production, inositol phosphate turnover, opening K+ channels or closing Ca2+ channels.

subject areas

  • Amino Acid Sequence
  • Animals
  • Brain
  • Calcium Channels
  • Cloning, Molecular
  • Cyclic AMP
  • GTP-Binding Proteins
  • Galanin
  • Gene Expression
  • Humans
  • Inositol Phosphates
  • Melanoma
  • Models, Neurological
  • Molecular Sequence Data
  • Potassium Channels
  • Receptors, Galanin
  • Receptors, Gastrointestinal Hormone
  • Recombinant Fusion Proteins
  • Recombinant Proteins
  • Second Messenger Systems
  • Sequence Homology, Amino Acid
  • Signal Transduction
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Research

keywords

  • agonist
  • galanin
  • galanin receptor
  • peptide antagonist
  • receptor subtypes
  • signal transduction
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Identity

International Standard Serial Number (ISSN)

  • 0272-4340

Digital Object Identifier (DOI)

  • 10.1007/bf02071130

PubMed ID

  • 8719035
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Additional Document Info

start page

  • 653

end page

  • 673

volume

  • 15

issue

  • 6

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