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Focal nature of neurological disorders necessitates isotype-selective histone deacetylase (hdac) inhibitors

Academic Article
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Overview

authors

  • Thomas, Elizabeth

publication date

  • August 2009

journal

  • Molecular Neurobiology  Journal

abstract

  • Histone deacetylase (HDAC) inhibitors represent a promising new avenue of therapeutic options for a range of neurological disorders. Within any particular neurological disorder, neuronal damage or death is not widespread; rather, particular brain regions are preferentially affected. Different disorders exhibit distinct focal pathologies. Hence, understanding the region-specific effects of HDAC inhibitors is essential for targeting appropriate brain areas and reducing toxicity in unaffected areas. The outcome of HDAC inhibition depends on several factors, including the diversity in the central nervous system expression of HDAC enzymes, selectivity of a given HDAC inhibitor for different HDAC enzymes, and the presence or absence of cofactors necessary for enzyme function. This review will summarize brain regions associated with various neurological disorders and factors affecting the consequences of HDAC inhibition.

subject areas

  • Animals
  • Brain
  • Enzyme Inhibitors
  • Gene Expression Regulation
  • Histone Deacetylase Inhibitors
  • Histone Deacetylases
  • Humans
  • Isoenzymes
  • Nervous System Diseases
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Research

keywords

  • CNS
  • Clinical
  • Epigenetic
  • HDAC inhibitor
  • Histone deacetylase
  • Neurodegenerative
  • Specificity
  • Therapeutic
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Identity

International Standard Serial Number (ISSN)

  • 0893-7648

Digital Object Identifier (DOI)

  • 10.1007/s12035-009-8067-y

PubMed ID

  • 19396637
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Additional Document Info

start page

  • 33

end page

  • 45

volume

  • 40

issue

  • 1

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