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Organic & Biomolecular Chemistry

Journal
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Overview

articles

  • Recent applications of chiral phosphoric acids in palladium catalysis.  18:618-637. 2020
  • Rational design of a function-based selection method for genetically encoding acylated lysine derivatives.  17:6127-6130. 2019
  • The structure-based traceless specific fluorescence labeling of the smoothened receptor.  17:6136-6142. 2019
  • Binding orientation and reactivity of alkyl α,ω-dibromides in water-soluble cavitands.  17:5279-5282. 2019
  • Chemical composition of DNA-encoded libraries, past present and future.  17:4676-4688. 2019
  • Stereoselective functionalization of platensimycin and platencin by sulfa-Michael/aldol reactions.  17:4261-4272. 2019
  • Using reversible non-covalent and covalent bonds to create assemblies and equilibrating molecular networks that survive 5 molar urea.  17:2081-2086. 2019
  • A SNAP-tag fluorogenic probe mimicking the chromophore of the red fluorescent protein Kaede.  17:1906-1915. 2019
  • Identification of a lysine 4-hydroxylase from the glidobactin biosynthesis and evaluation of its biocatalytic potential.  17:1736-1739. 2019
  • Vinylogous acyl triflates as an entry point to α,β-disubstituted cyclic enones via Suzuki-Miyaura cross-coupling.  17:1796-1799. 2019
  • A designed protein binding-pocket to control excited-state intramolecular proton transfer fluorescence.  17:1076-1080. 2019
  • Tandem Diels-Alder/oxidation-aromatization reactions involving 2-styrylchromones and arynes.  16:6077-6085. 2018
  • Chemoenzymatic macrocycle synthesis using resorcylic acid lactone thioesterase domains.  16:5771-5779. 2018
  • Transition-metal-free synthesis of polysubstituted pyrrole derivatives via cyclization of methyl isocyanoacetate with aurone analogues.  16:5422-5426. 2018
  • Chiral NHC-catalyzed 1,3-dipolar 3+2 cycloaddition of azomethine imines with alpha-chloroaldehydes for the synthesis of bicyclic pyrazolidinones.  16:4433-4438. 2018
  • An asymmetric Mannich reaction of α-diazocarbonyl compounds and N-sulfonyl cyclic ketimines catalyzed by complexes generated from chiral and achiral phosphines with gold(i).  16:2923-2931. 2018
  • Design, synthesis, and biological evaluation of C7-functionalized DMXAA derivatives as potential human-STING agonists 2018
  • Glycosylation of a model proto-RNA nucleobase with non-ribose sugars: implications for the prebiotic synthesis of nucleosides.  16:1263-1271. 2018
  • Construction of tetrahydropyranoquinoline derivatives via an asymmetric organocatalytic aza-Michael-IED/HAD cascade reaction.  15:9630-9637. 2017
  • Engineering a periplasmic binding protein for amino acid sensors with improved binding properties.  15:8761-8769. 2017
  • Base-catalyzed diastereoselective trimerization of trifluoroacetone.  15:5131-5134. 2017
  • Asymmetric synthesis of vinylogous β-amino acids and their incorporation into mixed backbone oligomers.  15:3255-3264. 2017
  • The design and synthesis of an α-Gal trisaccharide epitope that provides a highly specific anti-Gal immune response.  15:2979-2992. 2017
  • Stevens rearrangement of thioethers with arynes: a facile access to multi-substituted β-keto thioethers.  15:2716-2720. 2017
  • Weinreb amide directed cross-coupling reaction between electron-deficient alkenes catalyzed by a rhodium catalyst.  15:1236-1244. 2017
  • Assessment of reagents for selenocysteine conjugation and the stability of selenocysteine adducts.  14:5141-5147. 2016
  • A mild preparation of alkynes from alkenyl triflates.  14:5591-5594. 2016
  • Chemoenzymatic synthesis and utilization of a SAM analog with an isomorphic nucleobase.  14:6189-6192. 2016
  • Cyclopropenation of internal alkynylsilanes and diazoacetates catalyzed by copper(I) N-heterocyclic carbene complexes.  14:1742-1747. 2016
  • Enantioselective polyene cyclizations.  14:5454-5467. 2016
  • Flexibility is important for inhibition of the MDM2/p53 protein-protein interaction by cyclic β-hairpins.  14:10386-10393. 2016
  • Scalable procedure for the fragmentation of hydroperoxides mediated by copper and iron tetrafluoroborate salts.  14:6197-6200. 2016
  • Selective inhibition of p97 by chlorinated analogues of dehydrocurvularin.  14:5918-5921. 2016
  • Thermodynamic origin of α-helix stabilization by side-chain cross-links in a small protein.  14:5768-5773. 2016
  • Solid phase synthesis of 1,3,4-oxadiazin-5 (6R)-one and 1,3,4-oxadiazol-2-one scaffolds from acyl hydrazides.  13:59-63. 2015
  • A concise synthesis of single components of partially sulfated oligomannans.  13:11550-11560. 2015
  • Copper-catalysed cross-coupling: an untapped potential.  13:4816-4827. 2015
  • Cyanine polyene reactivity: scope and biomedical applications.  13:7584-7598. 2015
  • Functional chromatographic technique for natural product isolation.  13:2255-2259. 2015
  • Receptor-templated stapling of intrinsically disordered peptide ligands.  13:4183-4189. 2015
  • Synthesis and application of a dual chiral [2.2]paracyclophane-based N-heterocyclic carbene in enantioselective β-boration of acyclic enones.  13:10691-10698. 2015
  • Multivalent glycosylated nanoparticles for studying carbohydrate-protein interactions.  12:5563-5573. 2014
  • Synthesis of sesquiterpene-inspired derivatives designed for covalent binding and their inhibition of the NF-κB pathway.  12:370-375. 2014
  • Comparison of backbone modification in protein β-sheets by α→γ residue replacement and α-residue methylation.  12:5375-5381. 2014
  • Folded alkyl chains in water-soluble capsules and cavitands.  12:6561-6563. 2014
  • Methods to enable the design of bioactive small molecules targeting RNA.  12:1029-1039. 2014
  • Protein backbone engineering as a strategy to advance foldamers toward the frontier of protein-like tertiary structure.  12:8796-8802. 2014
  • Support of academic synthetic chemistry using separation technologies from the pharmaceutical industry.  12:2161-2166. 2014
  • The mechanism of the NHC catalyzed aza-Morita-Baylis-Hillman reaction: insights into a new substrate-catalyzed bimolecular pathway.  12:2176-2179. 2014
  • Chemoenzymatic synthesis and in situ application of S-adenosyl-L-methionine analogs.  11:7606-7610. 2013
  • Copper(II)-catalyzed trifluoromethylation of N-aryl imines.  11:6242-6245. 2013
  • Chemical approaches for detection and destruction of nerve agents.  11:3936-3942. 2013
  • Synthesis and biological evaluation of new paclitaxel analogs and discovery of potent antitumor agents.  11:4154-4163. 2013
  • Synthesis of acylguanidine zanamivir derivatives as neuraminidase inhibitors and the evaluation of their bio-activities.  11:3943-3948. 2013
  • Synthesis of libraries of peptidomimetic compounds containing a 2-oxopiperazine unit in the main chain.  11:2088-2092. 2013
  • A cucurbit[8]uril sponge.  10:8587-8589. 2012
  • Alkadienyl and alkenyl itaconic acids (ceriporic acids G and H) from the selective white-rot fungus Ceriporiopsis subvermispora: a new class of metabolites initiating ligninolytic lipid peroxidation.  10:6432-6442. 2012
  • Bicyclic core estrogens as full antagonists: Synthesis, biological evaluation and structure-activity relationships of estrogen receptor ligands based on bridged oxabicyclic core arylsulfonamides.  10:8692-8700. 2012
  • Binding trimethyllysine and other cationic guests in water with a series of indole-derived hosts: large differences in affinity from subtle changes in structure.  10:6885-6892. 2012
  • Construction of highly functional α-amino nitriles via a novel multicomponent tandem organocatalytic reaction: a facile access to α-methylene γ-lactams.  10:2214-2217. 2012
  • Discovery of an entropically-driven small molecule streptavidin binder from nucleic acid-encoded libraries.  10:1502-1505. 2012
  • Gas extrusion in natural products total synthesis.  10:8383-8392. 2012
  • Synthetic approaches to a chiral 4-amino-3-hydroxy piperidine with pharmaceutical relevance.  10:5253-5257. 2012
  • Exploring the self-assembly of glycopeptides using a diphenylalanine scaffold.  9:5755-5761. 2011
  • Impact of sugar stereochemistry on natural killer T cell stimulation by bacterial glycolipids.  9:7659-7662. 2011
  • Protein assembly directed by synthetic molecular recognition motifs.  9:7296-7299. 2011
  • Synthesis of serine-based glycolipids as potential TLR4 activators.  9:2492-2504. 2011
  • Regioselective synthesis of di-c-glycosylflavones possessing anti-inflammation activities.  8:4451-4462. 2010
  • Combinatorial approach toward synthesis of small molecule libraries as bacterial transglycosylase inhibitors.  8:2586-2593. 2010
  • In water, on water, and by water: Mimicking nature's aldolases with organocatalysis and water.  8:4043-4050. 2010
  • Mechanism-based crosslinking as a gauge for functional interaction of modular synthases.  8:1769-1772. 2010
  • N-methylcysteine-mediated total chemical synthesis of ubiquitin thioester.  8:2392-2396. 2010
  • Preparation of FRET reporters to support chemical probe development.  8:4601-4606. 2010
  • Selective inhibition of ADAR2-catalyzed editing of the serotonin 2c receptor pre-mRNA by a helix-threading peptide.  8:4898-4904. 2010
  • Synthetic studies on the mycolactone core.  8:5159-5165. 2010
  • Clickable fluorescent dyes for multimodal bioorthogonal imaging.  7:5055-5058. 2009
  • Dynamic polythioesters via ring-opening polymerization of 1,4-thiazine-2,5-diones.  7:2878-2884. 2009
  • Intramolecular azide-alkyne [3 + 2] cycloaddition: versatile route to new heterocyclic structural scaffolds.  7:1921-1930. 2009
  • New development of glycan arrays.  7:2247-2254. 2009
  • The pyridinone-methide elimination.  7:4825-4828. 2009
  • Synthesis and evaluation of novel pyridine based PLG tripeptidomimetics.  6:1647-1654. 2008
  • A deep cavitand catalyzes the Diels-Alder reaction of bound maleimides.  5:3631-3636. 2007
  • A systems perspective to digital structures in molecular analysis.  5:214-222. 2007
  • Sialic acid and N-acyl sialic acid analog production by fermentation of metabolically and genetically engineered Escherichia coli.  5:1903-1909. 2007
  • α- and β-Stilbenosides as base-pair surrogates in DNA hairpins.  4:314-322. 2006
  • Geometry in digital molecular arrays.  4:3052-3055. 2006
  • Microtiter plate based chemistry and in situ screening: A useful approach for rapid inhibitor discovery.  4:1446-1457. 2006
  • One-pot chemo-enzymatic synthesis of reporter-modified proteins.  4:44-46. 2006
  • Sigma-chelation-directed C-H functionalizations using Pd(II) and Cu(II) catalysts: Regioselectivity, stereoselectivity and catalytic turnover.  4:4041-4047. 2006
  • Synthesis of iso-epoxy-amphidinolide n and des-epoxy-caribenolide i structures. Initial forays.  4:2119-2157. 2006
  • Synthesis of iso-epoxy-amphidinolide n and des-epoxy-caribenolide i structures. Revised strategy and final stages.  4:2158-2183. 2006
  • New aminocyclitols as modulators of glucosylceramide metabolism.  3:1195-1201. 2005
  • Preferred dimerization of tetra-tolyl- and tetra-tosylurea derivatives of flexible and rigidified calix[4]arenes.  2:3080-3084. 2004
  • The ins and outs of molecular encapsulation.  2:3051-3059. 2004
  • HIV-1 protease: Mechanism and drug discovery.  1:5-14. 2003
  • Metabolic engineering - a genetic toolbox for small molecule organic synthesis.  1:1-4. 2003
  • Discovery and optimization of non-steroidal FXR agonists from natural product-like libraries.  1:908-920. 2003
  • Molecular screening on a compact disc.  1:3244-3249. 2003
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Identity

International Standard Serial Number (ISSN)

  • 1477-0520

Electronic International Standard Serial Number (EISSN)

  • 1477-0539

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