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An essential role for protein synthesis in oncogenic cellular transformation

Academic Article
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Overview

authors

  • Bader, A. G.
  • Vogt, Peter K.

publication date

  • April 2004

journal

  • Oncogene  Journal

abstract

  • The induction and maintenance of oncogenic transformation requires interference with the controls that regulate translation and transcription. The PI 3-kinase pathway, which shows gain of function in numerous and diverse human cancers, generates signals that have a positive effect on the initiation of protein synthesis. Here we review the components of the PI 3-kinase signaling pathway and the mRNA-binding protein YB-1, exploring their roles in protein synthesis and oncogenic cell transformation.

subject areas

  • Animals
  • Cell Transformation, Neoplastic
  • Humans
  • PTEN Phosphohydrolase
  • Phosphatidylinositol 3-Kinases
  • Phosphoric Monoester Hydrolases
  • Protein Biosynthesis
  • Protein Serine-Threonine Kinases
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-akt
  • Ribosomal Protein S6 Kinases
  • Tumor Suppressor Proteins
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Research

keywords

  • Akt
  • P3k
  • Raptor
  • Rheb
  • TOR
  • TSC
  • YB-1
  • translation
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Identity

International Standard Serial Number (ISSN)

  • 0950-9232

Digital Object Identifier (DOI)

  • 10.1038/sj.onc.1207550

PubMed ID

  • 15094764
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Additional Document Info

start page

  • 3145

end page

  • 3150

volume

  • 23

issue

  • 18

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