Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

The structure of the neurotoxin-associated protein HA33/A from Clostridium botulinum suggests a reoccurring beta-trefoil fold in the progenitor toxin complex

Academic Article
uri icon
  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Arndt, J. W.
  • Gu, J.
  • Jaroszewski, L.
  • Schwarzenbacher, R.
  • Hanson, Michael
  • Lebeda, F. J.
  • Stevens, Raymond

publication date

  • March 2005

journal

  • Journal of Molecular Biology  Journal

abstract

  • The hemagglutinating protein HA33 from Clostridium botulinum is associated with the large botulinum neurotoxin secreted complexes and is critical in toxin protection, internalization, and possibly activation. We report the crystal structure of serotype A HA33 (HA33/A) at 1.5 A resolution that contains a unique domain organization and a carbohydrate recognition site. In addition, sequence alignments of the other toxin complex components, including the neurotoxin BoNT/A, hemagglutinating protein HA17/A, and non-toxic non-hemagglutinating protein NTNHA/A, suggests that most of the toxin complex consists of a reoccurring beta-trefoil fold.

subject areas

  • Amino Acid Sequence
  • Bacterial Proteins
  • Binding Sites
  • Carbohydrate Metabolism
  • Clostridium botulinum
  • Conserved Sequence
  • Crystallography, X-Ray
  • Models, Molecular
  • Molecular Sequence Data
  • Neurotoxins
  • Protein Binding
  • Protein Conformation
  • Protein Folding
  • Sequence Alignment
scroll to property group menus

Research

keywords

  • beta-trefoil
  • hemagglutinin
  • neurotoxin
  • progenitor toxin
  • sugar-binding
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0022-2836

Digital Object Identifier (DOI)

  • 10.1016/j.jmb.2004.12.039

PubMed ID

  • 15701519
scroll to property group menus

Additional Document Info

start page

  • 1083

end page

  • 1093

volume

  • 346

issue

  • 4

©2021 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support