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T cell activation enhancement by endogenous pMHC acts for both weak and strong agonists but varies with differentiation state

Academic Article
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Overview

authors

  • Yachi, Pia
  • Lotz, C.
  • Ampudia, J.
  • Gascoigne, Nicholas

publication date

  • October 2007

journal

  • Journal of Experimental Medicine  Journal

abstract

  • T cells are extremely sensitive in their ability to find minute amounts of antigenic peptide in the midst of many endogenous peptides presented on an antigen-presenting cell. The role of endogenous peptides in the recognition of foreign peptide and hence in T cell activation has remained controversial for CD8(+) T cell activation. We showed previously that in a CD8(+) T cell hybridoma, nonstimulatory endogenous peptides enhance T cell sensitivity to antigen by increasing the coreceptor function of CD8. However, others were not able to detect such enhancement in naive and activated CD8(+) T cells. Here, we show that endogenous peptides substantially enhance the ability of T cells to detect antigen, an effect measurable by up-regulation of activation or maturation markers and by increased effector function. This enhancement is most pronounced in thymocytes, moderate in naive T cells, and mild in effector T cells. The importance of endogenous peptides is inversely proportional to the agonist activity of the stimulatory peptide presented. Unlike for CD4(+) T cells, the T cell receptor of CD8(+) T cells does not distinguish between endogenous peptides for their ability to enhance antigen recognition.

subject areas

  • ATP-Binding Cassette Transporters
  • Animals
  • Antigen-Presenting Cells
  • CD4-Positive T-Lymphocytes
  • CD8-Positive T-Lymphocytes
  • Cell Differentiation
  • Lymphocyte Activation
  • Major Histocompatibility Complex
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Peptide Fragments
  • T-Lymphocytes
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Identity

PubMed Central ID

  • PMC2118480

International Standard Serial Number (ISSN)

  • 0022-1007

Digital Object Identifier (DOI)

  • 10.1084/jem.20062610

PubMed ID

  • 17954567
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Additional Document Info

start page

  • 2747

end page

  • 2757

volume

  • 204

issue

  • 11

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