Elucidating genetic diversity with oligonucleotide arrays

Academic Article

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• Research
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Overview

authors

• Kidgell, C.
• Winzeler, Elizabeth

publication date

• January 2005

journal

• Chromosome Research  Journal

abstract

• DNA microarrays, initially designed to measure gene expression levels, also provide an ideal platform for determining genetic diversity. Oligonucleotide microarrays, predominantly high-density oligonucleotide arrays, have emerged as the principal platforms for performing genome-wide diversity analysis. They have wide-ranging potential applications including comparative genomics, polymorphism discovery and genotyping. The identification of inheritable genetic markers also permits the analysis of quantitative traits, population studies and linkage analysis. In this review, we will discuss the application of oligonucleotide arrays, in particular high-density oligonucleotide arrays for elucidating genetic diversity and highlight some of the directions that the field may take.

subject areas

• Animals
• Genetic Linkage
• Genetic Markers
• Genetic Variation
• Genome
• Humans
• Inheritance Patterns
• Oligonucleotide Array Sequence Analysis
• Quantitative Trait Loci

Research

keywords

• DNA hybridization
• comparative genomics
• genetic diversity
• oligonucleotide arrays

Identity

International Standard Serial Number (ISSN)

• 0967-3849

Digital Object Identifier (DOI)

• 10.1007/s10577-005-1503-6

PubMed ID

• 15868417

Additional Document Info

start page

• 225

end page

• 235

volume

• 13

issue

• 3