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Control of cortical interneuron migration by neurotrophins and pi3-kinase signaling

Academic Article
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Overview

authors

  • Polleux, Franck
  • Whitford, K. L.
  • Dijkhuizen, P. A.
  • Vitalis, T.
  • Ghosh, A.

publication date

  • July 2002

journal

  • Development  Journal

abstract

  • During telencephalic development, cells from the medial ganglionic eminence (MGE) are thought to migrate to the neocortex to give rise to a majority of cortical GABAergic interneurons. By combining time-lapse video-microscopy, immunofluorescence and pharmacological perturbations in a new in vitro migration assay, we find that MGE-derived cells migrate through the entire extent of the cortex and into the CA fields of the hippocampus, but avoid the dentate gyrus. Migrating neurons initially travel within the marginal zone and intermediate zone, and can enter the cortical plate from either location. Tangential migration is strongly stimulated by BDNF and NT4 and attenuated by the Trk-family inhibitor, K252a, suggesting that migration is regulated by TrkB signaling. Furthermore, TrkB-null mice show a significant decrease in the number of calbindin-positive neurons migrating tangentially in the embryonic cortex. BDNF and NT4 cause rapid activation of PI3-kinase in MGE cells, and inhibition of PI3-kinase (but not of MAP kinase or PLCgamma) dramatically attenuates tangential migration. These observations suggest that TrkB signaling, via PI3-kinase activation, plays an important role in controlling interneuron migration in the developing cerebral cortex.

subject areas

  • Animals
  • Brain-Derived Neurotrophic Factor
  • Carbazoles
  • Cell Movement
  • Cell Transplantation
  • Cells, Cultured
  • Cerebral Cortex
  • Chromones
  • Coculture Techniques
  • Enzyme Inhibitors
  • Female
  • Ganglia, Sensory
  • Green Fluorescent Proteins
  • Indole Alkaloids
  • Isoenzymes
  • Luminescent Proteins
  • Mice
  • Mice, Mutant Strains
  • Morpholines
  • Nerve Growth Factors
  • Neurons
  • Phosphatidylinositol 3-Kinases
  • Phospholipase C gamma
  • Receptor, trkB
  • Signal Transduction
  • Type C Phospholipases
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Research

keywords

  • CNS/inigration
  • interneuron
  • mouse
  • neurotrophins
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Identity

International Standard Serial Number (ISSN)

  • 0950-1991

PubMed ID

  • 12070090
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Additional Document Info

start page

  • 3147

end page

  • 3160

volume

  • 129

issue

  • 13

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