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A dynamical study of antibody-antigen encounter reactions

Academic Article
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Overview

authors

  • Bongini, L.
  • Fanelli, D.
  • Piazza, F.
  • De Los Rios, P.
  • Sanner, Michel
  • Skoglund, U.

publication date

  • September 2007

journal

  • Physical Biology  Journal

abstract

  • The effects of internal dynamics in diffusion-driven encounters between macro-molecules represent a problem of broad relevance in molecular biology. In this view, we investigate a typical antigen-antibody reaction chain, based on a coarse-grained mechanical model parameterized directly upon results from single-molecule experiments. We demonstrate that the internal dynamics is a crucial factor in the encounter process. To describe our numerical results, we formulate a simple, intuitive theoretical framework, and we develop it analytically. This enables us to show that the inner dynamics of antibody molecules results in a cooperative behavior of their individual sub-units. Along the same lines, we also investigate the case of double binding to multi-valent antigens. Our results quantify the enhancement of avidity afforded by the double binding in excellent agreement with the available experimental data.

subject areas

  • Animals
  • Antibodies
  • Antibody Affinity
  • Antigen-Antibody Complex
  • Antigen-Antibody Reactions
  • Antigens
  • Binding Sites, Antibody
  • Computer Simulation
  • Kinetics
  • Models, Chemical
  • Models, Immunological
  • Protein Binding
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Identity

International Standard Serial Number (ISSN)

  • 1478-3967

Digital Object Identifier (DOI)

  • 10.1088/1478-3975/4/3/004

PubMed ID

  • 17928656
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Additional Document Info

start page

  • 172

end page

  • 180

volume

  • 4

issue

  • 3

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