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Phospholipase Cγ2 is essential in the functions of B cell and several Fc receptors

Academic Article
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Overview

authors

  • Wang, D. M.
  • Wen, R. R.
  • Marine, J. C.
  • Sangster, M. Y.
  • Parganas, E.
  • Hoffmeyer, A.
  • Jackson, C. W.
  • Cleveland, John
  • Ihle, J. N.

publication date

  • July 2000

journal

  • Immunity  Journal

abstract

  • Many receptors activate phospholipase Cgamma1 or -gamma2. To assess the role of PLCgamma2, we derived enzyme-deficient mice. The mice are viable but have decreased mature B cells, a block in pro-B cell differentiation, and B1 B cell deficiency. IgM receptor-induced Ca2+ flux and proliferation to B cell mitogens are absent. IgM, IgG2a, and IgG3 levels are reduced, and T cell-independent antibody production is absent. The similarity to Btk- or Blnk-deficient mice demonstrates that PLCgamma2 is downstream in Btk/Blnk signaling. FcRgamma signaling is also defective, resulting in a loss of collagen-induced platelet aggregation, mast cell FcepsilonR function, and NK cell FcgammaRIII and 2B4 function. The results define a signal transduction pathway broadly utilized by immunoglobulin superfamily receptors.

subject areas

  • Adaptor Proteins, Signal Transducing
  • Animals
  • B-Lymphocytes
  • Blood Platelets
  • Carrier Proteins
  • Hematopoiesis
  • Isoenzymes
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Phospholipase C gamma
  • Phosphoproteins
  • Protein-Tyrosine Kinases
  • Receptors, Antigen, B-Cell
  • Receptors, IgG
  • Type C Phospholipases
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Identity

International Standard Serial Number (ISSN)

  • 1074-7613

Digital Object Identifier (DOI)

  • 10.1016/s1074-7613(00)00005-4

PubMed ID

  • 10933392
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Additional Document Info

start page

  • 25

end page

  • 35

volume

  • 13

issue

  • 1

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