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Restricted feeding-induced sleep, activity, and body temperature changes in normal and preproghrelin-deficient mice

Academic Article
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Overview

authors

  • Szentirmai, E.
  • Kapas, L.
  • Sun, Y. X.
  • Smith, Roy
  • Krueger, J. M.

publication date

  • February 2010

journal

  • American Journal of Physiology-Regulatory Integrative and Comparative Physiology  Journal

abstract

  • Behavioral and physiological rhythms can be entrained by daily restricted feeding (RF), indicating the existence of a food-entrainable oscillator (FEO). One manifestation of the presence of FEO is anticipatory activity to regularly scheduled feeding. In the present study, we tested if intact ghrelin signaling is required for FEO function by studying food anticipatory activity (FAA) in preproghrelin knockout (KO) and wild-type (WT) mice. Sleep-wake activity, locomotor activity, body temperature, food intake, and body weight were measured for 12 days in mice on a RF paradigm with food available only for 4 h daily during the light phase. On RF days 1-3, increases in arousal occurred. This response was significantly attenuated in preproghrelin KO mice. There were progressive changes in sleep architecture and body temperature during the subsequent nine RF days. Sleep increased at night and decreased during the light periods while the total daily amount of sleep remained at baseline levels in both KO and WT mice. Body temperature fell during the dark but was elevated during and after feeding in the light. In the premeal hours, anticipatory increases in body temperature, locomotor activity, and wakefulness were present from RF day 6 in both groups. Results indicate that the preproghrelin gene is not required for the manifestation of FAA but suggest a role for ghrelinergic mechanisms in food deprivation-induced arousal in mice.

subject areas

  • Animals
  • Arousal
  • Body Temperature
  • Body Weight
  • Caloric Restriction
  • Eating
  • Electroencephalography
  • Ghrelin
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Motor Activity
  • Sleep
  • Sleep, REM
  • Telemetry
  • Wakefulness
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Research

keywords

  • electroencephalographic slow-wave activity
  • food anticipatory activity
  • food deprivation
  • food-entrainable oscillator
  • hypothermia
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Identity

PubMed Central ID

  • PMC2828180

International Standard Serial Number (ISSN)

  • 0363-6119

Digital Object Identifier (DOI)

  • 10.1152/ajpregu.00557.2009

PubMed ID

  • 19939974
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Additional Document Info

start page

  • R467

end page

  • R477

volume

  • 298

issue

  • 2

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