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Role of receptor editing and revision in shaping the b and t lymphocyte repertoire

Academic Article
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Overview

authors

  • Kouskoff, V.
  • Nemazee, David

publication date

  • July 2001

journal

  • Life Sciences  Journal

abstract

  • B and T lymphocytes that carry antigen receptors are able to change specificity through subsequent receptor gene rearrangements. Receptor editing and receptor revision are terms used to distinguish those rearrangements occurring, respectively, in central lymphoid organs and the periphery. Secondary rearrangement appears to be a major player at two levels in the life of B lymphocytes. First, editing preserves a diverse repertoire without compromising self-tolerance, and revision further increases this repertoire once B cells have been engaged in an immune response, most likely for a better interaction with microbes. Recent studies have likewise suggested a role for receptor editing and revision in shaping the T cell repertoire during development and tolerance.

subject areas

  • Animals
  • B-Lymphocytes
  • Gene Rearrangement, B-Lymphocyte
  • Gene Rearrangement, T-Lymphocyte
  • Genes, Immunoglobulin
  • Humans
  • Receptors, Antigen, B-Cell
  • Receptors, Antigen, T-Cell
  • T-Lymphocytes
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Research

keywords

  • B lymphocyte
  • T lymphocyte
  • receptor editing
  • selection
  • tolerance
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Identity

International Standard Serial Number (ISSN)

  • 0024-3205

Digital Object Identifier (DOI)

  • 10.1016/s0024-3205(01)01219-x

PubMed ID

  • 11508343
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Additional Document Info

start page

  • 1105

end page

  • 1113

volume

  • 69

issue

  • 10

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