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Cross-reactive epitope with klebsiella-pneumoniae nitrogenase in articular tissue of hla-b27+ patients with ankylosing-spondylitis

Academic Article
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Overview

authors

  • Husby, G.
  • Tsuchiya, N.
  • Schwimmbeck, P. L.
  • Keat, A.
  • Pahle, J. A.
  • Oldstone, Michael
  • Williams, R. C.

publication date

  • April 1989

journal

  • Arthritis and Rheumatism  Journal

abstract

  • Synovial tissues from patients with ankylosing spondylitis or reactive arthritis were examined by an immunoperoxidase technique, using antisera to synthetic peptides representing antigens shared between HLA-B27.1 and Klebsiella pneumoniae nitrogenase. With either antiserum, all HLA-B27+ patients with synovial inflammation showed strong immunoperoxidase staining in synovial lining cells, vascular endothelium, and infiltrating inflammatory cells. These findings indicate that antigens showing cross-reactivity between HLA-B27.1 and Klebsiella nitrogenase epitopes are strongly expressed within inflamed synovial tissues of HLA-B27+ patients.

subject areas

  • Arthritis
  • Cartilage, Articular
  • Cross Reactions
  • Epitopes
  • HLA-B Antigens
  • HLA-B27 Antigen
  • Humans
  • Interferon-gamma
  • Klebsiella pneumoniae
  • Nitrogenase
  • Spondylitis, Ankylosing
  • Synovial Fluid
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Identity

International Standard Serial Number (ISSN)

  • 0004-3591

Digital Object Identifier (DOI)

  • 10.1002/anr.1780320413

PubMed ID

  • 2468338
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Additional Document Info

start page

  • 437

end page

  • 445

volume

  • 32

issue

  • 4

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