Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Tumor regression by targeted gene delivery to the neovasculature

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Hood, J. D.
  • Bednarski, M.
  • Frausto, R.
  • Guccione, S.
  • Reisfeld, Ralph
  • Xiang, R.
  • Cheresh, D. A.

publication date

  • 2002

journal

  • Science  Journal

abstract

  • Efforts to influence the biology of blood vessels by gene delivery have been hampered by a lack of targeting vectors specific for endothelial cells in diseased tissues. Here we show that a cationic nanoparticle (NP) coupled to an integrin alphavbeta3-targeting ligand can deliver genes selectively to angiogenic blood vessels in tumor-bearing mice. The therapeutic efficacy of this approach was tested by generating NPs conjugated to a mutant Raf gene, ATPmu-Raf, which blocks endothelial signaling and angiogenesis in response to multiple growth factors. Systemic injection of the NP into mice resulted in apoptosis of the tumor-associated endothelium, ultimately leading to tumor cell apoptosis and sustained regression of established primary and metastatic tumors.

subject areas

  • Adenosine Triphosphate
  • Animals
  • Apoptosis
  • Cations
  • Endothelium, Vascular
  • Gene Targeting
  • Gene Transfer Techniques
  • Genetic Therapy
  • Genetic Vectors
  • Humans
  • In Situ Nick-End Labeling
  • Ligands
  • Lipids
  • Melanoma, Experimental
  • Mice
  • Mice, Inbred BALB C
  • Mutation
  • Nanotechnology
  • Neoplasm Metastasis
  • Neoplasm Transplantation
  • Neoplasms, Experimental
  • Neovascularization, Pathologic
  • Proto-Oncogene Proteins c-raf
  • Random Allocation
  • Receptors, Vitronectin
  • Tumor Cells, Cultured
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.1070200

PubMed ID

  • 12089446
scroll to property group menus

Additional Document Info

start page

  • 2404

end page

  • 2407

volume

  • 296

issue

  • 5577

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support