recent publications
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academic article
- Roberts, V. A., Pique, M. E., Hsu, S., Li, S., Slupphaug, G., Rambo, R. P., Jamison, J. W., Liu, T., Lee, J. H., Tainer, J. A., Ten Eyck, L. F., Woods, V. L. Combining h/d exchange mass spectroscopy and computational docking reveals extended DNA-binding surface on uracil-DNA glycosylase Nucleic Acids Research 2012 40:6070-6081 DOI:10.1093/nar/gks291 PMID:22492624 PMCID:PMC3401472
- Sundheim, O., Vagbo, C. B., Bjoras, M., Sousa, M. M. L., Talstad, V., Aas, P. A., Drablos, F., Krokan, H. E., Tainer, J. A., Slupphaug, G. Human abh3 structure and key residues for oxidative demethylation to reverse DNA/rna damage EMBO Journal 2006 25:3389-3397 DOI:10.1038/sj.emboj.7601219 PMID:16858410 PMCID:PMC1523172
- Parikh, S. S., Walcher, G., Jones, G. D., Slupphaug, G., Krokan, H. E., Blackburn, G. M., Tainer, J. A. Uracil-DNA glycosylase-DNA substrate and product structures: Conformational strain promotes catalytic efficiency by coupled stereoelectronic effects Proceedings of the National Academy of Sciences of the United States of America 2000 97:5083-5088 DOI:10.1073/pnas.97.10.5083 PMID:10805771
- Parikh, S. S., Mol, C. D., Slupphaug, G., Bharati, S., Krokan, H. E., Tainer, J. A. Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA EMBO Journal 1998 17:5214-5226 DOI:10.1093/emboj/17.17.5214 PMID:9724657 PMCID:PMC1170849
- Slupphaug, G., Mol, C. D., Kavli, B., Arvai, A. S., Krokan, H. E., Tainer, J. A. A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA Nature 1996 384:87-92 DOI:10.1038/384087a0 PMID:8900285
- Kavli, B., Slupphaug, G., Mol, C. D., Arvai, A. S., Petersen, S. B., Tainer, J. A., Krokan, H. E. Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase EMBO Journal 1996 15:3442-3447 PMID:8670846 PMCID:PMC451908
- Mol, C. D., Arvai, A. S., Sanderson, R. J., Slupphaug, G., Kavli, B., Krokan, H. E., Mosbaugh, D. W., Tainer, J. A. Crystal-structure of human uracil-DNA glycosylase in complex with a protein inhibitor - protein mimicry of DNA Cell 1995 82:701-708 DOI:10.1016/0092-8674(95)90467-0 PMID:7671300
- Mol, C. D., Arvai, A. S., Slupphaug, G., Kavli, B., Alseth, I., Krokan, H. E., Tainer, J. A. Crystal-structure and mutational analysis of human uracil-DNA glycosylase - structural basis for specificity and catalysis Cell 1995 80:869-878 DOI:10.1016/0092-8674(95)90290-2 PMID:7697717