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5-HT(1A) receptor activation: short-term effects on the mRNA expression of the 5-HT(1A) receptor and galanin in the raphe nuclei

Academic Article
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Overview

authors

  • Razani, H.
  • Hedlund, Peter
  • Hansson, A. C.
  • Fuxe, K.
  • Ogren, S. O.

publication date

  • 1997

journal

  • Neuroreport  Journal

abstract

  • Systemic administration of the 5-HT1A receptor agonist 8-OH-2-(di-n-propylamino)-tetralin (8-OH-DPAT; 0.3 mg/kg, s.c.) was used to explore the effects of activation of 5-HT1A receptors on expression of mRNA coding for 5-HT1A receptor, tryptophan hydroxylase (TPH) and galanin in the ascending raphe nuclei. 8-OH-DPAT increased the hybridization signal of the 5-HT1A receptor by 105% in the dorsal raphe nucleus (B7) 30 min after the injection. No effects were seen at the later time points (2-8 h). In the median raphe nucleus (B8) and the B9 cell group in the medial lemniscus, 8-OH-DPAT induced a marked decrease in labeling 30 min after injection. At 8 h following 8-OH-DPAT injection, the effect had shifted to an increase in 5-HT1A receptor labeling by 68% in the B8 area. Importantly 8-OH-DPAT had no significant effects on the expression of mRNA coding for TPH and galanin. The results suggest an important and differential mechanism for the regulation of 5-HT1A receptor mRNA levels in the dorsal and median raphe nuclei. This regulation may be of importance for the differential control of the activity of the ascending 5-HT neurons, and hence for mood regulation. The results also indicate a dissociation between the effects mediated by 5-HT1A receptor functions and those regulating the coexisting peptide galanin in the dorsal raphe.

subject areas

  • 8-Hydroxy-2-(di-n-propylamino)tetralin
  • Animals
  • Antisense Elements (Genetics)
  • Galanin
  • Gene Expression Regulation
  • Kinetics
  • Male
  • RNA, Messenger
  • Raphe Nuclei
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Serotonin
  • Receptors, Serotonin, 5-HT1
  • Transcription, Genetic
  • Tryptophan Hydroxylase
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Identity

International Standard Serial Number (ISSN)

  • 0959-4965

Digital Object Identifier (DOI)

  • 10.1097/00001756-199711100-00029

PubMed ID

  • 9427327
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Additional Document Info

start page

  • 3565

end page

  • 3570

volume

  • 8

issue

  • 16

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