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The structure of pariacoto virus reveals a dodecahedral cage of duplex rna

Academic Article
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Overview

authors

  • Tang, L.
  • Johnson, K. N.
  • Ball, L. A.
  • Lin, T. W.
  • Yeager, Mark
  • Johnson Jr., John

publication date

  • January 2001

journal

  • Nature Structural Biology  Journal

abstract

  • The 3.0 A resolution crystal structure of Pariacoto virus (PaV) reveals extensive interactions between portions of the viral RNA genome and the icosahedral capsid. Under the protein shell of the T = 3 quasi equivalent capsid lies a dodecahedral cage composed of RNA duplex that accounts for approximately 35% of the single-stranded RNA genome. The highly basic N-terminal regions (residues 7-54) of the subunits, forming pentamers (A subunits) are clearly visible in the density map and make numerous interactions with the RNA cage. The C-terminal segments (residues 394-401) of the A subunits lie in channels near the quasi three-fold axes. Electron cryo-microscopy and image reconstruction of PaV particles clearly show the dodecahedral RNA cage.

subject areas

  • Amino Acid Sequence
  • Animals
  • Capsid
  • Cryoelectron Microscopy
  • Crystallography, X-Ray
  • Genome, Viral
  • Insect Viruses
  • Models, Molecular
  • Molecular Sequence Data
  • Mutation
  • Nucleic Acid Conformation
  • Protein Structure, Quaternary
  • Protein Structure, Secondary
  • Protein Subunits
  • RNA Viruses
  • RNA, Viral
  • Sequence Alignment
  • Spodoptera
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Identity

International Standard Serial Number (ISSN)

  • 1072-8368

PubMed ID

  • 11135676
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Additional Document Info

start page

  • 77

end page

  • 83

volume

  • 8

issue

  • 1

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