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Receptor for motilin identified in the human gastrointestinal system

Academic Article
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Overview

authors

  • Feighner, S. D.
  • Tan, C. P.
  • McKee, K. K.
  • Palyha, O. C.
  • Hreniuk, D. L.
  • Pong, S. S.
  • Austin, C. P.
  • Figueroa, D.
  • MacNeil, D.
  • Cascieri, M. A.
  • Nargund, R.
  • Bakshi, R.
  • Abramovitz, M.
  • Stocco, R.
  • Kargman, S.
  • O'Neill, G.
  • Van der Ploeg, L. H. T.
  • Evans, J.
  • Patchett, A. A.
  • Smith, Roy
  • Howard, A. D.

publication date

  • June 1999

journal

  • Science  Journal

abstract

  • Motilin is a 22-amino acid peptide hormone expressed throughout the gastrointestinal (GI) tract of humans and other species. It affects gastric motility by stimulating interdigestive antrum and duodenal contractions. A heterotrimeric guanosine triphosphate-binding protein (G protein)-coupled receptor for motilin was isolated from human stomach, and its amino acid sequence was found to be 52 percent identical to the human receptor for growth hormone secretagogues. The macrolide antibiotic erythromycin also interacted with the cloned motilin receptor, providing a molecular basis for its effects on the human GI tract. The motilin receptor is expressed in enteric neurons of the human duodenum and colon. Development of motilin receptor agonists and antagonists may be useful in the treatment of multiple disorders of GI motility.

subject areas

  • Alternative Splicing
  • Amino Acid Sequence
  • Base Sequence
  • Binding Sites
  • Calcium
  • Cell Line
  • Chromosome Mapping
  • Chromosomes, Human, Pair 13
  • Cloning, Molecular
  • Colon
  • Erythromycin
  • GTP-Binding Proteins
  • Humans
  • In Situ Hybridization
  • Intestine, Small
  • Ligands
  • Molecular Sequence Data
  • Motilin
  • Receptors, Gastrointestinal Hormone
  • Receptors, Neuropeptide
  • Stomach
  • Thyroid Gland
  • Transfection
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Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.284.5423.2184

PubMed ID

  • 10381885
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Additional Document Info

start page

  • 2184

end page

  • 2188

volume

  • 284

issue

  • 5423

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