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Effects of terguride, ropinirole, and acetyl-l-carnitine on methamphetamine withdrawal in the rat

Academic Article
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Overview

authors

  • Hoefer, M. E.
  • Voskanian, S. J.
  • Koob, George
  • Pulvirenti, Luigi

publication date

  • March 2006

journal

  • Pharmacology, Biochemistry and Behavior  Journal

abstract

  • Withdrawal from psychostimulants, including methamphetamine, induces a depressive state associated with lethargy, dysphoria, hyperphagia and psychomotor retardation. Previous work with repeated administration of amphetamine in rats has shown that amphetamine withdrawal produces decreased motivation to work for a non-drug reward, and this withdrawal is reversed by administration of a dopamine partial agonist. The purpose of the present study was to examine decreased motivation to work for a non-drug reward during methamphetamine withdrawal and explore the effects of a dopamine agonist, dopamine partial agonist, and indirect monoamine agonist on methamphetamine withdrawal. During withdrawal from repeated methamphetamine administration, rats showed reduced responding for a sweet solution in a progressive-ratio schedule of reinforcement, and this effect was significantly more pronounced than previously observed with amphetamine. Repeated systemic treatment with the dopamine partial agonist terguride (0.2 and 0.4 mg/kg, i.p., twice daily), the full dopamine agonist ropinirole (1 mg/kg, i.p., twice daily), and acetyl-L-carnitine (60 and 100 mg/kg, i.p.), a compound with a potential antidepressant effect, during methamphetamine withdrawal restored responding for the sweet solution, suggesting that these drugs may represent potential therapeutic strategies for the treatment of methamphetamine addiction during the withdrawal phase.

subject areas

  • Acetylcarnitine
  • Animals
  • Antidepressive Agents
  • Conditioning, Operant
  • Dopamine Agonists
  • Indoles
  • Lisuride
  • Male
  • Methamphetamine
  • Motivation
  • Rats
  • Rats, Wistar
  • Substance Withdrawal Syndrome
  • Sweetening Agents
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Research

keywords

  • acetyl-L-carnitine
  • dopamine
  • drug addiction
  • methamphetamine
  • partial agonist
  • withdrawal
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Identity

International Standard Serial Number (ISSN)

  • 0091-3057

Digital Object Identifier (DOI)

  • 10.1016/j.pbb.2006.02.023

PubMed ID

  • 16647107
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Additional Document Info

start page

  • 403

end page

  • 409

volume

  • 83

issue

  • 3

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