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Monoclonal autoantibody from a (New Zealand black x New Zealand white)F1 mouse and some human scleroderma sera target an Mr 34,000 nucleolar protein of the U3 RNP particle

Academic Article
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Overview

authors

  • Reimer, G.
  • Pollard, Kenneth Michael
  • Penning, C. A.
  • Ochs, R. L.
  • Lischwe, M. A.
  • Busch, H.
  • Tan, Eng

publication date

  • July 1987

journal

  • Arthritis and Rheumatism  Journal

abstract

  • A monoclonal IgG2a antinucleolar autoantibody (72B9) was obtained by fusion of spleen cells from a (New Zealand black x New Zealand white)F1 mouse with myeloma cells (P3x63Ag8.653). Antibody 72B9 recognized a highly conserved nucleolar antigen present in both animal and plant cells. The staining pattern produced by antibody 72B9 in different cell substrates was identical with those obtained by scleroderma antibodies reactive with a basic (pI 8.5) nucleolar protein of Mr 34,000, which is associated with the U3 RNP particle. Western blotting further confirmed its reactivity with this scleroderma-related U3 RNP protein.

subject areas

  • Animals
  • Antibodies, Monoclonal
  • Autoantibodies
  • Binding Sites, Antibody
  • Epitopes
  • Female
  • Fluorescent Antibody Technique
  • Humans
  • Hybridomas
  • Mice
  • Ribonucleoproteins
  • Scleroderma, Systemic
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Identity

International Standard Serial Number (ISSN)

  • 0004-3591

Digital Object Identifier (DOI)

  • 10.1002/art.1780300709

PubMed ID

  • 2441711
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Additional Document Info

start page

  • 793

end page

  • 800

volume

  • 30

issue

  • 7

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