Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

Genetics of SLE in mice

Academic Article
uri icon
  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Kono, Dwight
  • Theofilopoulos, Argyrios

publication date

  • October 2006

journal

  • Springer Seminars in Immunopathology  Journal

abstract

  • Genetic studies in spontaneous, induced, and gene-manipulated mouse models of SLE have provided significant insights into the potential number and diversity of genes that can promote, resist, and modify lupus susceptibility. Novel genes and mechanisms of disease pathogenesis have also been identified. Importantly, mouse models have provided an initial view of the genomic landscape of lupus-affecting genes, and have documented the complexities of verifying and determining the role of specific candidate loci and genes. Mouse models of lupus should continue to serve as a vital approach to defining the genetics of SLE.

subject areas

  • Animals
  • Disease Models, Animal
  • Genetic Predisposition to Disease
  • Genome, Human
  • Humans
  • Lupus Erythematosus, Systemic
  • Mice
  • Quantitative Trait Loci
scroll to property group menus

Research

keywords

  • animal models
  • genes
  • loci
  • lupus
  • susceptibility
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0344-4325

Digital Object Identifier (DOI)

  • 10.1007/s00281-006-0030-7

PubMed ID

  • 16972052
scroll to property group menus

Additional Document Info

start page

  • 83

end page

  • 96

volume

  • 28

issue

  • 2

©2021 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support