Pd-catalyzed intermolecular C-H amination with alkylamines

Academic Article
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related to degree

  • Chan, Kelvin, Ph.D. in Organic Chemistry, Scripps Research 2010 - 2015
  • Mei, Tian-Sheng, Ph.D. in Chemistry, Scripps Research , transferred from Brandeis Univeristy 2007 - 2011

publication date

  • 2011

abstract

  • C-H amination of N-aryl benzamides with O-benzoyl hydroxylamines has been achieved with either Pd(II) or Pd(0) catalysts. Furthermore, we demonstrate that secondary amines can be directly used with benzoyl peroxide in a one-pot procedure that proceeds via the in situ generation of the appropriate O-benzoyl hydroxylamines. This catalytic reaction provides a new disconnection for the convergent synthesis of tertiary and secondary arylalkyl amines starting from benzoic acids.