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Facile purification of rare cucurbiturils by affinity chromatography

Academic Article
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Overview

authors

  • Sasmal, S.
  • Sinha, M. K.
  • Keinan, Ehud

publication date

  • April 2004

journal

  • Organic Letters  Journal

abstract

  • A practical method for the separation and purification of cucurbituril (CB) hexamers was developed on the basis of affinity chromatography using aminopentylaminomethylated polystyrene beads. This recyclable resin, which can be used repeatedly, facilitates the general preparation of cucurbituril derivatives and compensates for the usually moderate yields and mixed products that characterize the acid-catalyzed synthesis of CB derivatives. This technique allows convenient, rapid isolation of rare substituted cucurbiturils, including hexacyclohexanocucurbit[6]uril and dodecamethylcucurbit[6]uril. [reaction: see text]

subject areas

  • Bridged Compounds
  • Catalysis
  • Chromatography, Affinity
  • Imidazoles
  • Indicators and Reagents
  • Methylation
  • Models, Molecular
  • Polystyrenes
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Identity

International Standard Serial Number (ISSN)

  • 1523-7060

Digital Object Identifier (DOI)

  • 10.1021/ol0499755

PubMed ID

  • 15070303
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Additional Document Info

start page

  • 1225

end page

  • 1228

volume

  • 6

issue

  • 8

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