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The role of RNP, Sm, and SS-A/Ro-specific antisera from patients with lupus erythematosus in inducing antibody-dependent cellular cytotoxicity (ADCC) of targets coated with nonhistone nuclear antigens

Academic Article
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Overview

authors

  • Norris, D. A.
  • Ryan, S. R.
  • Fritz, K. A.
  • Kubo, M.
  • Tan, Eng
  • Deng, J. S.
  • Weston, W. L.

publication date

  • 1984

journal

  • Clinical Immunology and Immunopathology  Journal

abstract

  • To better understand potential antibody-dependent mechanisms of tissue damage in lupus erythematosus (LE), an examination of whether antibodies to nonhistone nuclear antigens in LE patients' sera can induce ADCC of cellular targets coated with the corresponding antigens was undertaken. With high titer anti-RNP sera, significant ADCC was seen with monocyte (P less than 0.01), T-lymphocyte (P less than 0.001), and low-density lymphocyte (P less than 0.001) effectors. Using monocyte effectors, significant ADCC was seen with anti-RNP (P less than 0.01), anti-Sm (P less than 0.01), and anti-SSA/Ro (P less than 0.01), with the most profound lysis being with the anti-SSA/Ro sera. Neutrophils were ineffective in any nuclear antigen-antibody system tested. The effective mononuclear cell-mediated ADCC seen with anti-RNP, anti-Sm, and anti-SSA antisera may be related to the mononuclear cell-associated tissue change seen in cutaneous lupus lesions.

subject areas

  • Antibodies
  • Antibodies, Antinuclear
  • Antibody-Dependent Cell Cytotoxicity
  • Blood Group Antigens
  • Humans
  • Immune Sera
  • Lupus Erythematosus, Systemic
  • Lymphocytes
  • Monocytes
  • Nucleoproteins
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Identity

International Standard Serial Number (ISSN)

  • 0090-1229

Digital Object Identifier (DOI)

  • 10.1016/0090-1229(84)90084-9

PubMed ID

  • 6609040
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Additional Document Info

start page

  • 311

end page

  • 320

volume

  • 31

issue

  • 3

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