Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Liquid-crystalline collapse of pulmonary surfactant monolayers

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Schief, William
  • Antia, M.
  • Discher, B. M.
  • Hall, S. B.
  • Vogel, V.

publication date

  • June 2003

journal

  • Biophysical Journal  Journal

abstract

  • During exhalation, the surfactant film of lipids and proteins that coats the alveoli in the lung is compressed to high surface pressures, and can remain metastable for prolonged periods at pressures approaching 70 mN/m. Monolayers of calf lung surfactant extract (CLSE), however, collapse in vitro, during an initial compression at approximately 45 mN/m. To gain information on the source of this discrepancy, we investigated how monolayers of CLSE collapse from the interface. Observations with fluorescence, Brewster angle, and light scattering microscopies show that monolayers containing CLSE, CLSE-cholesterol (20%), or binary mixtures of dipalmitoyl phosphatidylcholine(DPPC)-dihydrocholesterol all form bilayer disks that reside above the monolayer. Upon compression and expansion, lipids flow continuously from the monolayer into the disks, and vice versa. In several respects, the mode of collapse resembles the behavior of other amphiphiles that form smectic liquid-crystal phases. These findings suggest that components of surfactent films must collapse collectively rather than being squeezed out individually.

subject areas

  • 1,2-Dipalmitoylphosphatidylcholine
  • Animals
  • Bronchoalveolar Lavage Fluid
  • Cattle
  • Cholestanol
  • Crystallography
  • Hydrostatic Pressure
  • Lipid Bilayers
  • Lung
  • Membrane Fluidity
  • Molecular Conformation
  • Phase Transition
  • Pulmonary Surfactants
  • Solubility
  • Surface Properties
scroll to property group menus

Identity

PubMed Central ID

  • PMC1302961

International Standard Serial Number (ISSN)

  • 0006-3495

Digital Object Identifier (DOI)

  • 10.1016/S0006-3495(03)75107-8

PubMed ID

  • 12770885
scroll to property group menus

Additional Document Info

start page

  • 3792

end page

  • 3806

volume

  • 84

issue

  • 6

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support