recent publications

• academic article

  • Wang, P., Zhou, Z., Hu, A., de Albuquerque, C. P., Zhou, Y., Hong, L., Sierecki, E., Ajiro, M., Kruhlak, M., Harris, C., Guan, K. L., Zheng, Z. M., et al. Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt Molecular Cell  2014 54:378-391  DOI:10.1016/j.molcel.2014.03.007  PMID:24703948  PMCID:PMC4019712
  • Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., Ahn, H. J., Ait-Mohamed, O., et al. Guidelines for the use and interpretation of assays for monitoring autophagy Autophagy  2012 8:445-544  DOI:10.4161/auto.19496  PMID:22966490  PMCID:PMC3404883
  • Zheng, M., Wang, Y. H., Wu, X. N., Wu, S. Q., Lu, B. J., Dong, M. Q., Zhang, H. B., Sun, P. Q., Lin, S. C., Guan, K. L., Han, J. H. Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1 Nature Cell Biology  2011 13:263-272  DOI:10.1038/ncb2168  PMID:21336308  PMCID:PMC3070924
  • Jiang, Y., Li, Z. J., Schwarz, E. M., Lin, A. N., Guan, K. L., Ulevitch, R. J., Han, J. H. Structure-function studies of p38 mitogen-activated protein kinase - loop 12 influences substrate specificity and autophosphorylation, but not upstream kinase selection Journal of Biological Chemistry  1997 272:11096-11102  PMID:9111004
  • Zhang, Z. Y., Zhou, G. C., Denu, J. M., Wu, L., Tang, X. J., Mondesert, O., Russell, P., Butch, E., Guan, K. L. Purification and characterization of the low molecular weight protein tyrosine phosphatase, Stp1, from the fission yeast Schizosaccharomyces pombe Biochemistry  1995 34:10560-10568  DOI:10.1021/bi00033a031  PMID:7654712
  • Millar, J. B. A., Russell, P., Dixon, J. E., Guan, K. L. Negative regulation of mitosis by two functionally overlapping PTPases in fission yeast EMBO Journal  1992 11:4943-4952  PMID:1464319  PMCID:PMC556972