Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Myosin II motor activity in the lateral amygdala is required for fear memory consolidation

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Gavin, C. F.
  • Rubio, M. D.
  • Young, E.
  • Miller, Courtney
  • Rumbaugh, Gavin

publication date

  • January 2012

journal

  • Learning & Memory  Journal

abstract

  • Learning induces dynamic changes to the actin cytoskeleton that are required to support memory formation. However, the molecular mechanisms that mediate filamentous actin (F-actin) dynamics during learning and memory are poorly understood. Myosin II motors are highly expressed in actin-rich growth structures including dendritic spines, and we have recently shown that these molecular machines mobilize F-actin in response to synaptic stimulation and learning in the hippocampus. In this study, we report that Myosin II motors in the rat lateral amygdala (LA) are essential for fear memory formation. Pretraining infusions of the Myosin II inhibitor, blebbistatin (blebb), disrupted long term memory, while short term memory was unaffected. Interestingly, both post-training and pretesting infusions had no effect on memory formation, indicating that Myosin II motors operate during or shortly after learning to promote memory consolidation. These data support the idea that Myosin II motor-force generation is a general mechanism that supports memory consolidation in the mammalian CNS.

subject areas

  • Amygdala
  • Animals
  • Association Learning
  • Conditioning, Classical
  • Dendritic Spines
  • Fear
  • Heterocyclic Compounds with 4 or More Rings
  • Hippocampus
  • Male
  • Memory
  • Nonmuscle Myosin Type IIB
  • Rats
  • Rats, Sprague-Dawley
  • Synapses
scroll to property group menus

Identity

PubMed Central ID

  • PMC3246591

International Standard Serial Number (ISSN)

  • 1072-0502

Digital Object Identifier (DOI)

  • 10.1101/lm.024042.111

PubMed ID

  • 22174310
scroll to property group menus

Additional Document Info

start page

  • 9

end page

  • 14

volume

  • 19

issue

  • 1

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support