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Rabbit beta-globin messenger-rna production in mouse l-cells transformed with cloned rabbit beta-globin chromosomal DNA

Academic Article
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Overview

authors

  • Mantei, N.
  • Boll, W.
  • Weissmann, Charles

publication date

  • 1979

journal

  • Nature  Journal

abstract

  • Mouse thymidine kinase-negative L cells were transformed with a cloned rabbit chromosomal beta-globin gene linked to the clone thymidine kinase gene of herpes simplex virus type 1. Most thymidine kinase-positive cell lines contained one or more copies of rabbit beta-globin DNA and produced up to 2,000 copies of rabbit beta-globin RNA per cell indistinguishable from its authentic counterpart. No mouse beta-globin mRNA was detected.

subject areas

  • Animals
  • Cloning, Molecular
  • DNA, Recombinant
  • Globins
  • L Cells (Cell Line)
  • Mice
  • RNA, Messenger
  • Rabbits
  • Thymidine Kinase
  • Transcription, Genetic
  • Transformation, Genetic
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Identity

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/281040a0

PubMed ID

  • 551266
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Additional Document Info

start page

  • 40

end page

  • 46

volume

  • 281

issue

  • 5726

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