recent publications
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academic article
- Schmidt, R. J., Ficorilli, J. V., Zhang, Y. Y., Bramlett, K. S., Beyer, T. P., Borchert, K., Dowless, M. S., Houck, K. A., Burris, T. P., Eacho, P. I., Liang, G. S., Guo, L. W., et al. A 15-ketosterol is a liver X receptor ligand that suppresses sterol-responsive element binding protein-2 activity Journal of Lipid Research 2006 47:1037-1044 DOI:10.1194/jlr.M500526-JLR200 PMID:16415294
- Thomas, J., Bramlett, K. S., Montrose, C., Foxworthy, P., Eacho, P. I., McCann, D., Cao, G. Q., Kiefer, A., McCowan, J., Yu, K. L., Grese, T., Chin, W. W., et al. A chemical switch regulates fibrate specificity for peroxisome proliferator-activated receptor alpha (ppar alpha) versus liver x receptor Journal of Biological Chemistry 2003 278:2403-2410 DOI:10.1074/jbc.M209629200 PMID:12441342
- Bramlett, K. S., Houck, K. A., Borchert, K. M., Dowless, M. S., Kulanthaivel, P., Zhang, Y. Y., Beyer, T. P., Schmidt, R., Thomas, J. S., Michael, L. F., Barr, R., Montrose, C., et al. A natural product ligand of the oxysterol receptor, liver x receptor Journal of Pharmacology and Experimental Therapeutics 2003 307:291-296 DOI:10.1124/jpet.103.052852 PMID:12893846
- Cao, G. Q., Liang, Y., Broderick, C. L., Oldham, B. A., Beyer, T. P., Schmidt, R. J., Zhang, Y. Y., Stayrook, K. R., Suen, C., Otto, K. A., Miller, A. R., Dai, J. N., et al. Antidiabetic action of a liver x receptor agonist mediated by inhibition of hepatic gluconeogenesis Journal of Biological Chemistry 2003 278:1131-1136 DOI:10.1074/jbc.M210208200 PMID:12414791
- Burris, T. P., Eacho, P. I., Cao, G. Q. Genetic disorders associated with atp binding cassette cholesterol transporters Molecular Genetics and Metabolism 2002 77:13-20 DOI:10.1016/s1096-7192(02)00144-0 PMID:12359125
- Zhang, Y. Y., Beyer, T. P., Bramlett, K. S., Yao, S. F., Burris, T. P., Schmidt, R. J., Eacho, P. I., Cao, G. Q. Liver x receptor and retinoic x receptor mediated abca1 regulation and cholesterol efflux in macrophage cells - messenger rna measured by branched DNA technology Molecular Genetics and Metabolism 2002 77:150-158 DOI:10.1016/s1096-7192(02)00111-7 PMID:12359143
- Nicolaou, K. C.*, Roecker, A. J.*, Pfefferkorn, J. A., Cao, G. Q. A novel strategy for the solid-phase synthesis of substituted indolines Journal of the American Chemical Society 2000 122:2966-2967 DOI:10.1021/ja994373f (* = equal contribution)
- Nicolaou, K. C.*, Pfefferkorn, J. A.*, Schuler, F., Roecker, A. J., Cao, G. Q., Casida, J. E. Combinatorial synthesis of novel and potent inhibitors of NADH:ubiquinone oxidoreductase Chemistry & Biology 2000 7:979-992 DOI:10.1016/s1074-5521(00)00047-8 PMID:11137820 (* = equal contribution)
- Nicolaou, K. C.*, Pfefferkorn, J. A.*, Roecker, A. J., Cao, G. Q., Barluenga, S., Mitchell, H. J. Natural product-like combinatorial libraries based on privileged structures. 1. General principles and solid-phase synthesis of benzopyrans Journal of the American Chemical Society 2000 122:9939-9953 DOI:10.1021/ja002033k (* = equal contribution)
- Nicolaou, K. C.*, Pfefferkorn, J. A.*, Mitchell, H. J., Roecker, A. J., Barluenga, S., Cao, G. Q., Affleck, R. L., Lillig, J. E. Natural product-like combinatorial libraries based on privileged structures. 2. Construction of a 10 000-membered benzopyran library by directed split-and-pool chemistry using nanokans and optical encoding Journal of the American Chemical Society 2000 122:9954-9967 DOI:10.1021/ja002034c (* = equal contribution)
- Nicolaou, K. C.*, Pfefferkorn, J. A.*, Barluenga, S., Mitchell, H. J., Roecker, A. J., Cao, G. Q. Natural product-like combinatorial libraries based on privileged structures. 3. The "libraries from libraries" principle for diversity enhancement of benzopyran libraries Journal of the American Chemical Society 2000 122:9968-9976 DOI:10.1021/ja0020355 (* = equal contribution)
- Nicolaou, K. C., Cao, G. Q., Pfefferkorn, J. A. Selenium-based solid-phase synthesis of benzopyrans II: Applications to combinatorial synthesis of medicinally relevant small organic molecules Angewandte Chemie-International Edition 2000 39:739-743 DOI:10.1002/(sici)1521-3773(20000218)39:4<739::aid-anie739>3.0.co;2-z PMID:10760853
- Nicolaou, K. C.*, Pfefferkorn, J. A.*, Cao, G. Q. Selenium-based solid-phase synthesis of benzopyrans i: Applications to combinatorial synthesis of natural products Angewandte Chemie-International Edition 2000 39:734-739 DOI:10.1002/(sici)1521-3773(20000218)39:4<734::aid-anie734>3.0.co;2-i PMID:10760852 (* = equal contribution)
- Nicolaou, K. C.*, Pfefferkorn, J. A.*, Cao, G. Q., Kim, S., Kessabi, J. A facile method for the solution and solid-phase synthesis of substituted 3.3.1 bicycles Organic Letters 1999 1:807-810 DOI:10.1021/ol990791d PMID:10823208 (* = equal contribution)