recent publications

• academic article

  • Xu, K., Ma, L., Li, Y., Wang, F., Zheng, G. Y., Sun, Z., Jiang, F., Chen, Y., Liu, H., Dang, A., Chen, X., Chun, J., et al. Genetic and functional evidence supports LPAR1 as a susceptibility gene for hypertension Hypertension  2015 66:641-646  DOI:10.1161/hypertensionaha.115.05515  PMID:26123684
  • Chen, Y., Huang, W. C., Sejourne, J., Clipperton-Allen, A. E., Page, D. T. Pten mutations alter brain growth trajectory and allocation of cell types through elevated β-catenin signaling Journal of Neuroscience  2015 35:10252-10267  DOI:10.1523/jneurosci.5272-14.2015  PMID:26180201
  • Zhao, Y., Gong, P., Chen, Y., Nwachukwu, J. C., Srinivasan, S., Ko, C., Bagchi, M. K., Taylor, R. N., Korach, K. S., Nettles, K. W., Katzenellenbogen, J. A., Katzenellenbogen, B. S. Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis Science Translational Medicine  2015 7:271ra9  DOI:10.1126/scitranslmed.3010626  PMID:25609169  PMCID:PMC4790140
  • Liu, C., Li, Z., Wang, L., Tong, L., He, N., Chen, Y., Liu, Y., Wu, Z., Sun, P., Xiang, R., Ren, G., Su, W. C. Activating transcription factor 4 promotes angiogenesis of breast cancer through enhanced macrophage recruitment Biomed Research International  2015 974615  DOI:10.1155/2015/974615  PMID:25883982  PMCID:PMC4391610
  • Chen, Y., Zhang, L., Estaras, C., Choi, S. H., Moreno Jr., L., Karn, J., Moresco, J. J., Yates III, J. R., Jones, K. A. A gene-specific role for the Ssu72 RNAPII CTD phosphatase in HIV-1 Tat transactivation Genes & Development  2014 28:2261-2275  DOI:10.1101/gad.250449.114  PMID:25319827  PMCID:PMC4201287
  • McDonald, W., Funatogawa, C., Li, Y., Chen, Y., Szundi, I., Fee, J. A., Stout, C. D., Einarsdottir, O. Conserved glycine 232 in the ligand channel of ba(3) cytochrome oxidase from Thermus thermophilus Biochemistry  2014 53:4467-4475  DOI:10.1021/bi500289h  PMID:24937405  PMCID:PMC4216187
  • Gammon, D. B., Duraffour, S., Rozelle, D. K., Hehnly, H., Sharma, R., Sparks, M. E., West, C. C., Chen, Y., Moresco, J. J., Andrei, G., Connor, J. H., Conte, D., et al. A single vertebrate DNA virus protein disarms invertebrate immunity to RNA virus infection Elife  2014 3:e02910  DOI:10.7554/eLife.02910  PMID:24966209  PMCID:PMC4112549
  • Chen, S., Li, X., Lu, D., Xu, Y., Mou, W., Wang, L., Chen, Y., Liu, Y., Li, X., Li, L. Y., Liu, L., Stupack, D., et al. SOX2 regulates apoptosis through MAP4K4-survivin signaling pathway in human lung cancer cells Carcinogenesis  2014 35:613-623  DOI:10.1093/carcin/bgt371  PMID:24233838
  • Bisogno, T., Mahadevan, A., Coccurello, R., Chang, J. W., Allara, M., Chen, Y., Giacovazzo, G., Lichtman, A., Cravatt, B., Moles, A., Di Marzo, V. A novel fluorophosphonate inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol with potential anti-obesity effects British Journal of Pharmacology  2013 169:784-793  DOI:10.1111/bph.12013  PMID:23072382  PMCID:PMC3687659
  • Liao, H. X., Lynch, R., Zhou, T., Gao, F., Alam, S. M., Boyd, S. D., Fire, A. Z., Roskin, K. M., Schramm, C. A., Zhang, Z., Zhu, J., Shapiro, L., et al. Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus Nature  2013 496:469-476  DOI:10.1038/nature12053  PMID:23552890  PMCID:PMC3637846
  • McDonald, W., Funatogawa, C., Li, Y., Szundi, I., Chen, Y., Fee, J. A., Stout, C. D., Einarsdottir, O. Ligand access to the active site in thermus thermophilus ba(3) and bovine heart aa(3) cytochrome oxidases Biochemistry  2013 52:640-652  DOI:10.1021/bi301358a  PMID:23282175  PMCID:PMC3569493
  • Regateiro, F. S., Chen, Y., Kendal, A. R., Hilbrands, R., Adams, E., Cobbold, S. P., Ma, J., Andersen, K. G., Betz, A. G., Zhang, M., Madhiwalla, S., Roberts, B., et al. Foxp3 expression is required for the induction of therapeutic tissue tolerance Journal of Immunology  2012 189:3947-3956  DOI:10.4049/jimmunol.1200449  PMID:22988034  PMCID:PMC3467196
  • Neehaul, Y., Chen, Y., Werner, C., Fee, J. A., Ludwig, B., Hellwig, P. Electrochemical and infrared spectroscopic analysis of the interaction of the cu-a domain and cytochrome c(552) from thermus thermophilus Biochimica et Biophysica Acta-Bioenergetics  2012 1817:1950-1954  DOI:10.1016/j.bbabio.2012.02.027  PMID:22402225
  • Koppaka, V., Thompson, D. C., Chen, Y., Ellermann, M., Nicolaou, K. C., Juvonen, R. O., Petersen, D., Deitrich, R. A., Hurley, T. D., Vasiliou, V. Aldehyde dehydrogenase inhibitors: A comprehensive review of the pharmacology, mechanism of action, substrate specificity, and clinical application Pharmacological Reviews  2012 64:520-539  DOI:10.1124/pr.111.005538  PMID:22544865  PMCID:PMC3400832
  • Chen, Y., Adams, E., Regateiro, F. S., Vaux, D. J., Betz, A. G., Andersen, K. G., Waldmann, H., Howie, D. Activation rather than Foxp3 expression determines that TGF-β-induced regulatory T cells out-compete naïve T cells in dendritic cell clustering European Journal of Immunology  2012 42:1436-1448  DOI:10.1002/eji.201142207  PMID:22678900
  • Jia, H. Q., Pallos, J., Jacques, V., Lau, A., Tang, B., Cooper, A., Syed, A., Purcell, J., Chen, Y., Sharma, S., Sangrey, G. R., Darnell, S. B., et al. Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of huntington's disease Neurobiology of Disease  2012 46:351-361  DOI:10.1016/j.nbd.2012.01.016  PMID:22590724  PMCID:PMC3528106
  • Chang, H. Y., Choi, S. K., Vakkasoglu, A. S., Chen, Y., Hemp, J., Fee, J. A., Gennis, R. B. Exploring the proton pump and exit pathway for pumped protons in cytochrome ba(3) from thermus thermophilus Proceedings of the National Academy of Sciences of the United States of America  2012 109:5259-5264  DOI:10.1073/pnas.1107345109  PMID:22431640  PMCID:PMC3325665
  • Liu, B., Zhang, Y., Sage, J. T., Soltis, S. M., Doukov, T., Chen, Y., Stout, C. D., Fee, J. A. Structural changes that occur upon photolysis of the fe(ii)(a3)-co complex in the cytochrome ba(3)-oxidase of thermus thermophilus: A combined x-ray crystallographic and infrared spectral study demonstrates co binding to cu-b Biochimica et Biophysica Acta-Bioenergetics  2012 1817:658-665  DOI:10.1016/j.bbabio.2011.12.2010  PMID:22226917  PMCID:PMC3294259
  • Egawa, T., Chen, Y., Fee, J. A., Yeh, S. R., Rousseau, D. L. The rate-limiting step in o-2 reduction by cytochrome ba(3) from thermus thermophilus Biochimica et Biophysica Acta-Bioenergetics  2012 1817:666-671  DOI:10.1016/j.bbabio.2011.11.010  PMID:22138627  PMCID:PMC3294028
  • Jiang, C. L., Parrish, N. F., Wilen, C. B., Li, H., Chen, Y., Pavlicek, J. W., Berg, A., Lu, X. Z., Song, H. S., Tilton, J. C., Pfaff, J. M., Henning, E. A., et al. Primary infection by a human immunodeficiency virus with atypical coreceptor tropism Journal of Virology  2011 85:10669-10681  DOI:10.1128/jvi.05249-11  PMID:21835785  PMCID:PMC3187499
  • Tiefenbrunn, T., Liu, W., Chen, Y., Katritch, V., Stout, C. D., Fee, J. A., Cherezov, V. High resolution structure of the ba3 cytochrome c oxidase from thermus thermophilus in a lipidic environment PLoS One  2011 6:e22348  DOI:10.1371/journal.pone.0022348  PMID:21814577  PMCID:PMC3141039
  • Breuer, S., Sepulveda, H., Chen, Y., Trotter, J., Torbett, B. E. A cleavage enzyme-cytometric bead array provides biochemical profiling of resistance mutations in HIV-1 Gag and protease Biochemistry  2011 50:4371-4381  DOI:10.1021/bi200031m  PMID:21452835  PMCID:PMC3159576
  • Chen, Y., Zhou, Y. S., Qiu, S. M., Wang, K. J., Liu, S. W., Peng, X. X., Li, J. F., Tan, E. M., Zhang, J. Y. Autoantibodies to tumor-associated antigens combined with abnormal alpha-fetoprotein enhance immunodiagnosis of hepatocellular carcinoma Cancer Letters  2010 289:32-39  DOI:10.1016/j.canlet.2009.07.016  PMID:19683863  PMCID:PMC2823929
  • Chang, H. Y., Hemp, J., Chen, Y., Fee, J. A., Gennis, R. B. The cytochrome ba(3) oxygen reductase from thermus thermophilus uses a single input channel for proton delivery to the active site and for proton pumping Proceedings of the National Academy of Sciences of the United States of America  2009 106:16169-16173  DOI:10.1073/pnas.0905264106  PMID:19805275  PMCID:PMC2752507
  • Hayashi, T., Lin, M. T., Ganesan, K., Chen, Y., Fee, J. A., Gennis, R. B., Moenne-Loccoz, P. Accommodation of two diatomic molecules in cytochrome bo(3): Insights into no reductase activity in terminal oxidases Biochemistry  2009 48:883-890  DOI:10.1021/bi801915r  PMID:19187032  PMCID:PMC2651033
  • Liu, B., Chen, Y., Doukov, T., Soltis, S. M., Stout, C. D., Fee, J. A. Combined microspectrophotometric and crystallographic examination of chemically reduced and x-ray radiation-reduced forms of cytochrome ba(3) oxidase from thermus thermophilus: Structure of the reduced form of the enzymes Biochemistry  2009 48:820-826  DOI:10.1021/bi801759a  PMID:19140675  PMCID:PMC2638058
  • Chen, Y., Wendt-Pienkowski, E., Shen, B. Identification and utility of fdmr1 as a streptomyces antibiotic regulatory protein activator for fredericamycin production in streptomyces griseus atcc 49344 and heterologous hosts Journal of Bacteriology  2008 190:5587-5596  DOI:10.1128/jb.00592-08  PMID:18556785  PMCID:PMC2519381
  • Chen, Y., Rao, F., Rodriguez-Flores, J. L., Mahapatra, N. R., Mahata, M., Wen, G., Salem, R. M., Shih, P. A. B., Das, M., Schork, N. J., Ziegler, M. G., Hamilton, B. A., et al. Common genetic variants in the chromogranin a promoter alter autonomic activity and blood pressure Kidney International  2008 74:115-125  DOI:10.1038/ki.2008.113  PMID:18432188  PMCID:PMC2576285
  • Luna, V. M., Chen, Y., Fee, J. A., Stout, C. D. Crystallographic studies of Xe and Kr binding within the large internal cavity of cytochrome ba3 from Thermus thermophilus: structural analysis and role of oxygen transport channels in the heme-Cu oxidases Biochemistry  2008 47:4657-4665  DOI:10.1021/bi800045y  PMID:18376849
  • Salem, R. M., Cadman, P. E., Chen, Y., Rao, F., Wen, G., Harnilton, B. A., Rana, B. K., Smith, D. W., Stridsberg, M., Ward, H. J., Mahata, M., Mahata, S. K., et al. Chromogranin a polymorphisms are associated with hypertensive renel disease Journal of the American Society of Nephrology  2008 19:600-614  DOI:10.1681/asn.2007070754  PMID:18235090  PMCID:PMC2391050
  • Cheng, T. J. R., Sung, M. T., Liao, H. Y., Chang, Y. F., Chen, C. W., Huang, C. Y., Chou, L. Y., Wu, Y. D., Chen, Y., Cheng, Y. S. E., Wong, C. H., Ma, C., et al. Domain requirement of moenomycin binding to bifunctional transglycosylases and development of high-throughput discovery of antibiotics Proceedings of the National Academy of Sciences of the United States of America  2008 105:431-436  DOI:10.1073/pnas.0710868105  PMID:18182485  PMCID:PMC2206553
  • Hayashi, T., Lin, I. J., Chen, Y., Fee, J. A., Moenne-Loccoz, P. Fourier transform infrared characterization of a cu-b-nitrosyl complex in cytochrome ba3 from thermus thermophilus: Relevance to no reductase activity in heme-copper terminal oxidases Journal of the American Chemical Society  2007 129:14952-14958  DOI:10.1021/ja074600a  PMID:17997553  PMCID:PMC2548420
  • Liu, B., Luna, V. M., Chen, Y., Stout, C. D., Fee, J. A. An unexpected outcome of surface engineering an integral membrane protein: Improved crystallization of cytochrome ba(3) from thermus thermophilus Acta Crystallographica Section F-Structural Biology and Crystallization Communications  2007 63:1029-1034  DOI:10.1107/s1744309107054176  PMID:18084085  PMCID:PMC2344090
  • Zhang, J. Y., Megliorino, R., Peng, X. X., Tan, E. M., Chen, Y., Chan, E. K. L. Antibody detection using tumor-associated antigen mini-array in immunodiagnosing human hepatocellular carcinoma Journal of Hepatology  2007 46:107-114  DOI:10.1016/j.jhep.2006.08.010  PMID:17067715  PMCID:PMC2706782
  • Gorelsky, S. I., Xie, X. J., Chen, Y., Fee, J. A., Solomon, E. I. The two-state issue in the mixed-valence binuclear cu-a center in cytochrome c oxidase and n2o reductase Journal of the American Chemical Society  2006 128:16452-16453  DOI:10.1021/ja067583i  PMID:17177365
  • Lin, I. J., Chen, Y., Fee, J. A., Song, J. K., Westler, W. M., Markley, J. L. Rieske protein from thermus thermophilus: N-15 NMR titration study demonstrates the role of iron-ligated histidines in the ph dependence of the reduction potential Journal of the American Chemical Society  2006 128:10672-10673  DOI:10.1021/ja0627388  PMID:16910649
  • Farver, O., Chen, Y., Fee, J. A., Pecht, I. Electron transfer among the cu-a-, heme b- and a(3)-centers of thermus thermophilus cytochrome ba(3) FEBS Letters  2006 580:3417-3421  DOI:10.1016/j.febslet.2006.05.013  PMID:16712843
  • Chen, Y., Carroll, A. D., Scampavia, L., Ruzicka, J. Automated method, based on micro-sequential injection, for the study of enzyme kinetics and inhibition Analytical Sciences  2006 22:9-14  DOI:10.2116/analsci.22.9  PMID:16429764
  • Luo, G. H., Chen, Y., Siuzdak, G., Vertes, A. Surface modification and laser pulse length effects on internal energy transfer in dios Journal of Physical Chemistry B  2005 109:24450-24456  DOI:10.1021/jp054311d  PMID:16375447
  • Chen, Y., Hunsicker-Wang, L., Pacoma, R. L., Luna, E., Fee, J. A. A homologous expression system for obtaining engineered cytochrome ba(3) from thermus thermophilus hb8 Protein Expression and Purification  2005 40:299-318  DOI:10.1016/j.pep.2004.11.014  PMID:15766872
  • Hunsicker-Wang, L. M., Pacoma, R. L., Chen, Y., Fee, J. A., Stout, C. D. A novel cryoprotection scheme for enhancing the diffraction of crystals of recombinant cytochrome ba3 oxidase from thermus thermophilus Acta Crystallographica Section D-Biological Crystallography  2005 61:340-343  DOI:10.1107/s0907444904033906  PMID:15735345
  • Hunsicker-Wang, L. M., Heine, A., Chen, Y., Luna, E. P., Todaro, T., Zhang, Y. M., Williams, P. A., McRee, D. E., Hirst, J., Stout, C. D., Fee, J. A. High-resolution structure of the soluble, respiratory-type rieske protein from thermus thermophilus: Analysis and comparison Biochemistry  2003 42:7303-7317  DOI:10.1021/bi0342719  PMID:12809486
  • Chen, Y., Bilban, M., Foster, C. A., Boger, D. L. Solution-phase parallel synthesis of a pharmacophore library of hun-7293 analogues: a general chemical mutagenesis approach to defining structure-function properties of naturally occurring cyclic (depsi)peptides Journal of the American Chemical Society  2002 124:5431-5440  DOI:10.1021/ja020166v  PMID:11996584
  • Wang, G. K., Ousley, A., Darlington, T. K., Chen, D., Chen, Y., Fu, W., Hickman, L. J., Kay, S. A., Sehgal, A. Regulation of the cycling of timeless (tim) RNA Journal of Neurobiology  2001 47:161-175  DOI:10.1002/neu.1024  PMID:11333398
  • McRee, D. E., Williams, P. A., Sridhar, V., Pastuszyn, A., Bren, K. L., Patel, K. M., Chen, Y., Todaro, T. R., Sanders, D., Luna, E., Fee, J. A. Recombinant cytochrome rc(557) obtained from escherichia coli cells expressing a truncated thermus thermophilus cyca gene - heme inversion in an improperly matured protein Journal of Biological Chemistry  2001 276:6537-6544  DOI:10.1074/jbc.M008421200  PMID:11069913
  • Fee, J. A., Chen, Y., Todaro, T. R., Bren, K. L., Patel, K. M., Hill, M. G., Gomez-Moran, E., Loehr, T. M., Ai, J. Y., Thony-Meyer, L., Williams, P. A., Stura, E., et al. Integrity of thermus thermophilus cytochrome c(552) synthesized by escherichia coli cells expressing the host-specific cytochrome c maturation genes, ccmabcdefgh. Biochemical, spectral, and structural characterization of the recombinant protein Protein Science  2000 9:2074-2084  DOI:10.1110/ps.9.11.2074  PMID:11152119  PMCID:PMC2144481
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