recent publications
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academic article
- Xu, K., Ma, L., Li, Y., Wang, F., Zheng, G. Y., Sun, Z., Jiang, F., Chen, Y., Liu, H., Dang, A., Chen, X., Chun, J., et al. Genetic and functional evidence supports LPAR1 as a susceptibility gene for hypertension Hypertension 2015 66:641-646 DOI:10.1161/hypertensionaha.115.05515 PMID:26123684
- Chen, Y., Huang, W. C., Sejourne, J., Clipperton-Allen, A. E., Page, D. T. Pten mutations alter brain growth trajectory and allocation of cell types through elevated β-catenin signaling Journal of Neuroscience 2015 35:10252-10267 DOI:10.1523/jneurosci.5272-14.2015 PMID:26180201
- Zhao, Y., Gong, P., Chen, Y., Nwachukwu, J. C., Srinivasan, S., Ko, C., Bagchi, M. K., Taylor, R. N., Korach, K. S., Nettles, K. W., Katzenellenbogen, J. A., Katzenellenbogen, B. S. Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis Science Translational Medicine 2015 7:271ra9 DOI:10.1126/scitranslmed.3010626 PMID:25609169 PMCID:PMC4790140
- Liu, C., Li, Z., Wang, L., Tong, L., He, N., Chen, Y., Liu, Y., Wu, Z., Sun, P., Xiang, R., Ren, G., Su, W. C. Activating transcription factor 4 promotes angiogenesis of breast cancer through enhanced macrophage recruitment Biomed Research International 2015 974615 DOI:10.1155/2015/974615 PMID:25883982 PMCID:PMC4391610
- Chen, Y., Zhang, L., Estaras, C., Choi, S. H., Moreno Jr., L., Karn, J., Moresco, J. J., Yates III, J. R., Jones, K. A. A gene-specific role for the Ssu72 RNAPII CTD phosphatase in HIV-1 Tat transactivation Genes & Development 2014 28:2261-2275 DOI:10.1101/gad.250449.114 PMID:25319827 PMCID:PMC4201287
- McDonald, W., Funatogawa, C., Li, Y., Chen, Y., Szundi, I., Fee, J. A., Stout, C. D., Einarsdottir, O. Conserved glycine 232 in the ligand channel of ba(3) cytochrome oxidase from Thermus thermophilus Biochemistry 2014 53:4467-4475 DOI:10.1021/bi500289h PMID:24937405 PMCID:PMC4216187
- Gammon, D. B., Duraffour, S., Rozelle, D. K., Hehnly, H., Sharma, R., Sparks, M. E., West, C. C., Chen, Y., Moresco, J. J., Andrei, G., Connor, J. H., Conte, D., et al. A single vertebrate DNA virus protein disarms invertebrate immunity to RNA virus infection Elife 2014 3:e02910 DOI:10.7554/eLife.02910 PMID:24966209 PMCID:PMC4112549
- Chen, S., Li, X., Lu, D., Xu, Y., Mou, W., Wang, L., Chen, Y., Liu, Y., Li, X., Li, L. Y., Liu, L., Stupack, D., et al. SOX2 regulates apoptosis through MAP4K4-survivin signaling pathway in human lung cancer cells Carcinogenesis 2014 35:613-623 DOI:10.1093/carcin/bgt371 PMID:24233838
- Bisogno, T., Mahadevan, A., Coccurello, R., Chang, J. W., Allara, M., Chen, Y., Giacovazzo, G., Lichtman, A., Cravatt, B., Moles, A., Di Marzo, V. A novel fluorophosphonate inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol with potential anti-obesity effects British Journal of Pharmacology 2013 169:784-793 DOI:10.1111/bph.12013 PMID:23072382 PMCID:PMC3687659
- Liao, H. X., Lynch, R., Zhou, T., Gao, F., Alam, S. M., Boyd, S. D., Fire, A. Z., Roskin, K. M., Schramm, C. A., Zhang, Z., Zhu, J., Shapiro, L., et al. Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus Nature 2013 496:469-476 DOI:10.1038/nature12053 PMID:23552890 PMCID:PMC3637846
- McDonald, W., Funatogawa, C., Li, Y., Szundi, I., Chen, Y., Fee, J. A., Stout, C. D., Einarsdottir, O. Ligand access to the active site in thermus thermophilus ba(3) and bovine heart aa(3) cytochrome oxidases Biochemistry 2013 52:640-652 DOI:10.1021/bi301358a PMID:23282175 PMCID:PMC3569493
- Regateiro, F. S., Chen, Y., Kendal, A. R., Hilbrands, R., Adams, E., Cobbold, S. P., Ma, J., Andersen, K. G., Betz, A. G., Zhang, M., Madhiwalla, S., Roberts, B., et al. Foxp3 expression is required for the induction of therapeutic tissue tolerance Journal of Immunology 2012 189:3947-3956 DOI:10.4049/jimmunol.1200449 PMID:22988034 PMCID:PMC3467196
- Neehaul, Y., Chen, Y., Werner, C., Fee, J. A., Ludwig, B., Hellwig, P. Electrochemical and infrared spectroscopic analysis of the interaction of the cu-a domain and cytochrome c(552) from thermus thermophilus Biochimica et Biophysica Acta-Bioenergetics 2012 1817:1950-1954 DOI:10.1016/j.bbabio.2012.02.027 PMID:22402225
- Koppaka, V., Thompson, D. C., Chen, Y., Ellermann, M., Nicolaou, K. C., Juvonen, R. O., Petersen, D., Deitrich, R. A., Hurley, T. D., Vasiliou, V. Aldehyde dehydrogenase inhibitors: A comprehensive review of the pharmacology, mechanism of action, substrate specificity, and clinical application Pharmacological Reviews 2012 64:520-539 DOI:10.1124/pr.111.005538 PMID:22544865 PMCID:PMC3400832
- Chen, Y., Adams, E., Regateiro, F. S., Vaux, D. J., Betz, A. G., Andersen, K. G., Waldmann, H., Howie, D. Activation rather than Foxp3 expression determines that TGF-β-induced regulatory T cells out-compete naïve T cells in dendritic cell clustering European Journal of Immunology 2012 42:1436-1448 DOI:10.1002/eji.201142207 PMID:22678900
- Jia, H. Q., Pallos, J., Jacques, V., Lau, A., Tang, B., Cooper, A., Syed, A., Purcell, J., Chen, Y., Sharma, S., Sangrey, G. R., Darnell, S. B., et al. Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of huntington's disease Neurobiology of Disease 2012 46:351-361 DOI:10.1016/j.nbd.2012.01.016 PMID:22590724 PMCID:PMC3528106
- Chang, H. Y., Choi, S. K., Vakkasoglu, A. S., Chen, Y., Hemp, J., Fee, J. A., Gennis, R. B. Exploring the proton pump and exit pathway for pumped protons in cytochrome ba(3) from thermus thermophilus Proceedings of the National Academy of Sciences of the United States of America 2012 109:5259-5264 DOI:10.1073/pnas.1107345109 PMID:22431640 PMCID:PMC3325665
- Liu, B., Zhang, Y., Sage, J. T., Soltis, S. M., Doukov, T., Chen, Y., Stout, C. D., Fee, J. A. Structural changes that occur upon photolysis of the fe(ii)(a3)-co complex in the cytochrome ba(3)-oxidase of thermus thermophilus: A combined x-ray crystallographic and infrared spectral study demonstrates co binding to cu-b Biochimica et Biophysica Acta-Bioenergetics 2012 1817:658-665 DOI:10.1016/j.bbabio.2011.12.2010 PMID:22226917 PMCID:PMC3294259
- Egawa, T., Chen, Y., Fee, J. A., Yeh, S. R., Rousseau, D. L. The rate-limiting step in o-2 reduction by cytochrome ba(3) from thermus thermophilus Biochimica et Biophysica Acta-Bioenergetics 2012 1817:666-671 DOI:10.1016/j.bbabio.2011.11.010 PMID:22138627 PMCID:PMC3294028
- Jiang, C. L., Parrish, N. F., Wilen, C. B., Li, H., Chen, Y., Pavlicek, J. W., Berg, A., Lu, X. Z., Song, H. S., Tilton, J. C., Pfaff, J. M., Henning, E. A., et al. Primary infection by a human immunodeficiency virus with atypical coreceptor tropism Journal of Virology 2011 85:10669-10681 DOI:10.1128/jvi.05249-11 PMID:21835785 PMCID:PMC3187499
- Tiefenbrunn, T., Liu, W., Chen, Y., Katritch, V., Stout, C. D., Fee, J. A., Cherezov, V. High resolution structure of the ba3 cytochrome c oxidase from thermus thermophilus in a lipidic environment PLoS One 2011 6:e22348 DOI:10.1371/journal.pone.0022348 PMID:21814577 PMCID:PMC3141039
- Breuer, S., Sepulveda, H., Chen, Y., Trotter, J., Torbett, B. E. A cleavage enzyme-cytometric bead array provides biochemical profiling of resistance mutations in HIV-1 Gag and protease Biochemistry 2011 50:4371-4381 DOI:10.1021/bi200031m PMID:21452835 PMCID:PMC3159576
- Chen, Y., Zhou, Y. S., Qiu, S. M., Wang, K. J., Liu, S. W., Peng, X. X., Li, J. F., Tan, E. M., Zhang, J. Y. Autoantibodies to tumor-associated antigens combined with abnormal alpha-fetoprotein enhance immunodiagnosis of hepatocellular carcinoma Cancer Letters 2010 289:32-39 DOI:10.1016/j.canlet.2009.07.016 PMID:19683863 PMCID:PMC2823929
- Chang, H. Y., Hemp, J., Chen, Y., Fee, J. A., Gennis, R. B. The cytochrome ba(3) oxygen reductase from thermus thermophilus uses a single input channel for proton delivery to the active site and for proton pumping Proceedings of the National Academy of Sciences of the United States of America 2009 106:16169-16173 DOI:10.1073/pnas.0905264106 PMID:19805275 PMCID:PMC2752507
- Hayashi, T., Lin, M. T., Ganesan, K., Chen, Y., Fee, J. A., Gennis, R. B., Moenne-Loccoz, P. Accommodation of two diatomic molecules in cytochrome bo(3): Insights into no reductase activity in terminal oxidases Biochemistry 2009 48:883-890 DOI:10.1021/bi801915r PMID:19187032 PMCID:PMC2651033
- Liu, B., Chen, Y., Doukov, T., Soltis, S. M., Stout, C. D., Fee, J. A. Combined microspectrophotometric and crystallographic examination of chemically reduced and x-ray radiation-reduced forms of cytochrome ba(3) oxidase from thermus thermophilus: Structure of the reduced form of the enzymes Biochemistry 2009 48:820-826 DOI:10.1021/bi801759a PMID:19140675 PMCID:PMC2638058
- Chen, Y., Wendt-Pienkowski, E., Shen, B. Identification and utility of fdmr1 as a streptomyces antibiotic regulatory protein activator for fredericamycin production in streptomyces griseus atcc 49344 and heterologous hosts Journal of Bacteriology 2008 190:5587-5596 DOI:10.1128/jb.00592-08 PMID:18556785 PMCID:PMC2519381
- Chen, Y., Rao, F., Rodriguez-Flores, J. L., Mahapatra, N. R., Mahata, M., Wen, G., Salem, R. M., Shih, P. A. B., Das, M., Schork, N. J., Ziegler, M. G., Hamilton, B. A., et al. Common genetic variants in the chromogranin a promoter alter autonomic activity and blood pressure Kidney International 2008 74:115-125 DOI:10.1038/ki.2008.113 PMID:18432188 PMCID:PMC2576285
- Luna, V. M., Chen, Y., Fee, J. A., Stout, C. D. Crystallographic studies of Xe and Kr binding within the large internal cavity of cytochrome ba3 from Thermus thermophilus: structural analysis and role of oxygen transport channels in the heme-Cu oxidases Biochemistry 2008 47:4657-4665 DOI:10.1021/bi800045y PMID:18376849
- Salem, R. M., Cadman, P. E., Chen, Y., Rao, F., Wen, G., Harnilton, B. A., Rana, B. K., Smith, D. W., Stridsberg, M., Ward, H. J., Mahata, M., Mahata, S. K., et al. Chromogranin a polymorphisms are associated with hypertensive renel disease Journal of the American Society of Nephrology 2008 19:600-614 DOI:10.1681/asn.2007070754 PMID:18235090 PMCID:PMC2391050
- Cheng, T. J. R., Sung, M. T., Liao, H. Y., Chang, Y. F., Chen, C. W., Huang, C. Y., Chou, L. Y., Wu, Y. D., Chen, Y., Cheng, Y. S. E., Wong, C. H., Ma, C., et al. Domain requirement of moenomycin binding to bifunctional transglycosylases and development of high-throughput discovery of antibiotics Proceedings of the National Academy of Sciences of the United States of America 2008 105:431-436 DOI:10.1073/pnas.0710868105 PMID:18182485 PMCID:PMC2206553
- Hayashi, T., Lin, I. J., Chen, Y., Fee, J. A., Moenne-Loccoz, P. Fourier transform infrared characterization of a cu-b-nitrosyl complex in cytochrome ba3 from thermus thermophilus: Relevance to no reductase activity in heme-copper terminal oxidases Journal of the American Chemical Society 2007 129:14952-14958 DOI:10.1021/ja074600a PMID:17997553 PMCID:PMC2548420
- Liu, B., Luna, V. M., Chen, Y., Stout, C. D., Fee, J. A. An unexpected outcome of surface engineering an integral membrane protein: Improved crystallization of cytochrome ba(3) from thermus thermophilus Acta Crystallographica Section F-Structural Biology and Crystallization Communications 2007 63:1029-1034 DOI:10.1107/s1744309107054176 PMID:18084085 PMCID:PMC2344090
- Zhang, J. Y., Megliorino, R., Peng, X. X., Tan, E. M., Chen, Y., Chan, E. K. L. Antibody detection using tumor-associated antigen mini-array in immunodiagnosing human hepatocellular carcinoma Journal of Hepatology 2007 46:107-114 DOI:10.1016/j.jhep.2006.08.010 PMID:17067715 PMCID:PMC2706782
- Gorelsky, S. I., Xie, X. J., Chen, Y., Fee, J. A., Solomon, E. I. The two-state issue in the mixed-valence binuclear cu-a center in cytochrome c oxidase and n2o reductase Journal of the American Chemical Society 2006 128:16452-16453 DOI:10.1021/ja067583i PMID:17177365
- Lin, I. J., Chen, Y., Fee, J. A., Song, J. K., Westler, W. M., Markley, J. L. Rieske protein from thermus thermophilus: N-15 NMR titration study demonstrates the role of iron-ligated histidines in the ph dependence of the reduction potential Journal of the American Chemical Society 2006 128:10672-10673 DOI:10.1021/ja0627388 PMID:16910649
- Farver, O., Chen, Y., Fee, J. A., Pecht, I. Electron transfer among the cu-a-, heme b- and a(3)-centers of thermus thermophilus cytochrome ba(3) FEBS Letters 2006 580:3417-3421 DOI:10.1016/j.febslet.2006.05.013 PMID:16712843
- Chen, Y., Carroll, A. D., Scampavia, L., Ruzicka, J. Automated method, based on micro-sequential injection, for the study of enzyme kinetics and inhibition Analytical Sciences 2006 22:9-14 DOI:10.2116/analsci.22.9 PMID:16429764
- Luo, G. H., Chen, Y., Siuzdak, G., Vertes, A. Surface modification and laser pulse length effects on internal energy transfer in dios Journal of Physical Chemistry B 2005 109:24450-24456 DOI:10.1021/jp054311d PMID:16375447
- Chen, Y., Hunsicker-Wang, L., Pacoma, R. L., Luna, E., Fee, J. A. A homologous expression system for obtaining engineered cytochrome ba(3) from thermus thermophilus hb8 Protein Expression and Purification 2005 40:299-318 DOI:10.1016/j.pep.2004.11.014 PMID:15766872
- Hunsicker-Wang, L. M., Pacoma, R. L., Chen, Y., Fee, J. A., Stout, C. D. A novel cryoprotection scheme for enhancing the diffraction of crystals of recombinant cytochrome ba3 oxidase from thermus thermophilus Acta Crystallographica Section D-Biological Crystallography 2005 61:340-343 DOI:10.1107/s0907444904033906 PMID:15735345
- Hunsicker-Wang, L. M., Heine, A., Chen, Y., Luna, E. P., Todaro, T., Zhang, Y. M., Williams, P. A., McRee, D. E., Hirst, J., Stout, C. D., Fee, J. A. High-resolution structure of the soluble, respiratory-type rieske protein from thermus thermophilus: Analysis and comparison Biochemistry 2003 42:7303-7317 DOI:10.1021/bi0342719 PMID:12809486
- Chen, Y., Bilban, M., Foster, C. A., Boger, D. L. Solution-phase parallel synthesis of a pharmacophore library of hun-7293 analogues: a general chemical mutagenesis approach to defining structure-function properties of naturally occurring cyclic (depsi)peptides Journal of the American Chemical Society 2002 124:5431-5440 DOI:10.1021/ja020166v PMID:11996584
- Wang, G. K., Ousley, A., Darlington, T. K., Chen, D., Chen, Y., Fu, W., Hickman, L. J., Kay, S. A., Sehgal, A. Regulation of the cycling of timeless (tim) RNA Journal of Neurobiology 2001 47:161-175 DOI:10.1002/neu.1024 PMID:11333398
- McRee, D. E., Williams, P. A., Sridhar, V., Pastuszyn, A., Bren, K. L., Patel, K. M., Chen, Y., Todaro, T. R., Sanders, D., Luna, E., Fee, J. A. Recombinant cytochrome rc(557) obtained from escherichia coli cells expressing a truncated thermus thermophilus cyca gene - heme inversion in an improperly matured protein Journal of Biological Chemistry 2001 276:6537-6544 DOI:10.1074/jbc.M008421200 PMID:11069913
- Fee, J. A., Chen, Y., Todaro, T. R., Bren, K. L., Patel, K. M., Hill, M. G., Gomez-Moran, E., Loehr, T. M., Ai, J. Y., Thony-Meyer, L., Williams, P. A., Stura, E., et al. Integrity of thermus thermophilus cytochrome c(552) synthesized by escherichia coli cells expressing the host-specific cytochrome c maturation genes, ccmabcdefgh. Biochemical, spectral, and structural characterization of the recombinant protein Protein Science 2000 9:2074-2084 DOI:10.1110/ps.9.11.2074 PMID:11152119 PMCID:PMC2144481
- Boger, D. L., Chen, Y., Foster, C. A. Synthesis and evaluation of aza HUN-7293 Bioorganic & Medicinal Chemistry Letters 2000 10:1741-1744 DOI:10.1016/s0960-894x(00)00336-x PMID:10937737
- Chen, Y., Case, D. A., Reizer, J., Saier, M. H., Wright, P. E. High-resolution solution structure of bacillus subtilis iia(glc) Proteins-Structure Function and Genetics 1998 31:258-270 DOI:10.1002/(sici)1097-0134(19980515)31:3<258::aid-prot3>3.3.co;2-q PMID:9593197
- Herrera-Marschitz, M., Goiny, M., You, Z. B., Meana, J. J., Engidawork, E., Chen, Y., Rodriguez-Puertas, R., Broberger, C., Andersson, K., Terenius, L., Hokfelt, T., Ungerstedt, U. Release of endogenous excitatory amino acids in the neostriatum of the rat under physiological and pharmacologically-induced conditions Amino Acids 1998 14:197-203 DOI:10.1007/bf01345262 PMID:9871461
- HerreraMarschitz, M., You, Z. B., Goiny, M., Meana, J. J., Silveira, R., Godukhin, O. V., Chen, Y., Espinoza, S., Pettersson, E., Loidl, C. F., Lubec, G., Andersson, K., et al. On the origin of extracellular glutamate levels monitored in the basal ganglia of the rat by in vivo microdialysis Journal of Neurochemistry 1996 66:1726-1735 PMID:8627331
- Chen, Y., Reizer, J., Saier, M. H., Fairbrother, W. J., Wright, P. E. Mapping of the binding interfaces of the proteins of the bacterial phosphotransferase system, hpr and iia(glc) Biochemistry 1993 32:32-37 DOI:10.1021/bi00052a006 PMID:8418852
- Chen, Y., Fairbrother, W. J., Wright, P. E. Three-dimensional structures of the central regulatory proteins of the bacterial phosphotransferase system, HPr and enzyme IIAglc Journal of Cellular Biochemistry 1993 51:75-82 DOI:10.1002/jcb.240510114 PMID:8432747
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- Ghadiri, M. R., Choi, C., Fernholz, A. K., Ruan, F., Chen, Y., Hopkins, P. B., Aube, J. Peptide architecture: design of stabilized alpha-helical metallopeptides Chemtracts: Organic Chemistry 1991 4:135-139