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In vivo roles of lysophospholipid receptors revealed by gene targeting studies in mice

Academic Article
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Overview

authors

  • Yang, A. H.
  • Ishii, I.
  • Chun, Jerold

publication date

  • May 2002

journal

  • Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids  Journal

abstract

  • Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are extracellular ligands for a family of G protein-coupled receptors (GPCRs), LPA1/2/3 and S1P1/2/3/4/5. Through coupling to multiple classes of G proteins and activating multiple signaling pathways, LPA/S1P receptors have been shown to be integral players for many essential cellular and physiological processes. Generation and analysis of mice deficient in each of LPA1, LPA2, S1P1, S1P2, and S1P3 have provided valuable information on the in vivo roles of these receptors. This review is focussed on expression patterns of each receptor gene in wild-type mice, targeted deletion approaches for generating mutant animals, main phenotypes of receptor-null mice, and alterations in signaling characteristics in receptor-deficient primary cells. Altogether, these data give insights to the importance of LPA/S1P receptors at the cellular and organismal level.

subject areas

  • Animals
  • Lysophospholipids
  • Mice
  • Mice, Knockout
  • Phenotype
  • Receptors, Cell Surface
  • Receptors, G-Protein-Coupled
  • Receptors, Lysophosphatidic Acid
  • Signal Transduction
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Research

keywords

  • LPA receptor
  • S1P receptor
  • lysophosphatidic acid
  • lysophospholipid
  • signal transduction
  • sphingosine 1-phosphate
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Identity

International Standard Serial Number (ISSN)

  • 1388-1981

Digital Object Identifier (DOI)

  • 10.1016/s1388-1981(02)00172-5

PubMed ID

  • 12069829
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Additional Document Info

start page

  • 197

end page

  • 203

volume

  • 1582

issue

  • 1-3

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