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Cachectin and tumor-necrosis-factor as 2 sides of the same biological coin

Academic Article
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Overview

authors

  • Beutler, Bruce
  • Cerami, A.

publication date

  • 1986

journal

  • Nature  Journal

abstract

  • In response to invasive stimuli macrophages secrete cachectin, a multipotent protein. Prominent among its biological effects is the ability to induce wasting (cachexia) as well as a lethal state of shock. The identity of cachectin and tumour necrosis factor has led to a new view of its therapeutic potential.

subject areas

  • Amino Acid Sequence
  • Animals
  • Antineoplastic Agents
  • Biological Evolution
  • Cachexia
  • Endotoxins
  • Genes
  • Glycoproteins
  • Humans
  • Lipoprotein Lipase
  • Lymphotoxin-alpha
  • Proteins
  • Receptors, Cell Surface
  • Receptors, Tumor Necrosis Factor
  • Sequence Homology, Nucleic Acid
  • Tumor Necrosis Factor-alpha
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Identity

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/320584a0

PubMed ID

  • 3010124
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Additional Document Info

start page

  • 584

end page

  • 588

volume

  • 320

issue

  • 6063

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