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The nerve growth factor/tumor necrosis factor receptor family

Academic Article
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Overview

authors

  • Lotz, Martin
  • Setareh, M.
  • vonKempis, J.
  • Schwarz, H.

publication date

  • July 1996

journal

  • Journal of Leukocyte Biology  Journal

abstract

  • Receptors in the nerve growth factor/tumor necrosis factor receptor family are characterized by the presence of cysteine-rich motifs of approximately 40 amino acids in the extracellular domain. The ligands are type II transmembrane proteins with beta-strands that form a jelly-roll beta-sandwich. The receptors recognize soluble or cell-surface-bound ligands and mediate diverse cellular responses. Activation of intracellular signals is mediated at least in part by the association of proteins with a RING finger motif or a death domain to the cytoplasmic domains of the receptors. In addition to cell-membrane-bound receptors soluble forms have been described for most of the receptors. Activation of intracellular signals not only occurs through ligand binding to the receptors but cross-linking of at least some members of the ligand family can regulate cell functions.

subject areas

  • Animals
  • Antigens, CD
  • Antigens, CD27
  • Antigens, CD30
  • Antigens, CD40
  • Antigens, CD95
  • Cysteine
  • Humans
  • Ligands
  • Protein Structure, Secondary
  • Receptors, Nerve Growth Factor
  • Receptors, Tumor Necrosis Factor
  • Signal Transduction
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Research

keywords

  • apoptosis
  • cell proliferation
  • differentiation
  • host defense
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Identity

International Standard Serial Number (ISSN)

  • 0741-5400

PubMed ID

  • 8699112
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Additional Document Info

start page

  • 1

end page

  • 7

volume

  • 60

issue

  • 1

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