Organellar proteomics: the prizes and pitfalls of opening the nuclear envelope Academic Article uri icon

publication date

  • 2002


  • Proteomic studies have the potential to comprehensively define the composition of organelles but are limited by the organellar cross-contamination that arises during subcellular fractionation. Comparative proteomics of organellar subfractions can mitigate these problems, as demonstrated by a recent study involving the nuclear envelope.