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Optimized protocols for the isolation of specific protein-binding peptides or peptoids from combinatorial libraries displayed on beads

Academic Article
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Overview

authors

  • Kodadek, Thomas
  • Bachhawat-Sikder, K.

publication date

  • January 2006

journal

  • Molecular Biosystems  Journal

abstract

  • Many methods have been published by which combinatorial libraries may be screened for compounds capable of manipulating the function(s) of a target protein. One of the simplest approaches is to identify compounds in a library that bind the protein of interest, since these binding events usually occur on functionally important surfaces of the protein. These protein-binding compounds could also be of utility as protein capture agents in the construction of protein-detecting microarrays or related analytical devices and as reagents for the affinity purification of proteins from complex mixtures. In this article, we provide optimized methods for screening libraries of molecules displayed on the beads on which they were synthesized. This is a particularly convenient format for library screening for laboratories with limited budgets and modest robotics capabilities.

subject areas

  • Chalcone
  • Combinatorial Chemistry Techniques
  • Kinetics
  • Ligands
  • Models, Molecular
  • Myelin Basic Protein
  • Peptide Library
  • Peptides
  • Protein Binding
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Identity

International Standard Serial Number (ISSN)

  • 1742-206X

Digital Object Identifier (DOI)

  • 10.1039/b514349g

PubMed ID

  • 16880920
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Additional Document Info

start page

  • 25

end page

  • 35

volume

  • 2

issue

  • 1

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