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Site-specific pegylation of proteins containing unnatural amino acids

Academic Article
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Overview

authors

  • Deiters, A.
  • Cropp, T. A.
  • Summerer, D.
  • Mukherji, M.
  • Schultz, Peter

publication date

  • December 2004

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

abstract

  • Here, we report a generally applicable PEGylation methodology based on the site-specific incorporation of para-azidophenylalanine into proteins in yeast. The azido group was used in a mild [3+2] cycloaddition reaction with an alkyne derivatized PEG reagent to afford selectively PEGylated protein. This strategy should be useful for the generation of selectively PEGylated proteins for therapeutic applications.

subject areas

  • Amino Acids
  • Humans
  • Polyethylene Glycols
  • Protein Binding
  • Superoxide Dismutase
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2004.09.059

PubMed ID

  • 15501033
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Additional Document Info

start page

  • 5743

end page

  • 5745

volume

  • 14

issue

  • 23

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