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Inhibition of the fibroblast growth-factor receptor 1 (fgfr-1) gene in human melanocytes and malignant melanomas leads to inhibition of proliferation and signs indicative of differentiation

Academic Article
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Overview

authors

  • Becker, D.
  • Lee, Pauline
  • Rodeck, U.
  • Herlyn, M.

publication date

  • November 1992

journal

  • Oncogene  Journal

abstract

  • Fibroblast growth factor receptor (FGFR-1) is expressed as a single 3.5-kb mRNA transcript in normal human melanocytes and in malignant melanomas as determined upon Northern hybridization to a cDNA clone encoding the membrane-spanning form of the human FGFR-1. Polyclonal antisera directed against the chicken FGFR recognized a 145-kDa protein in primary and metastatic melanomas. Antisense oligodeoxynucleotides targeted against the translation start site and a splice donor-acceptor site of human FGFR-1, in addition to inhibiting the proliferation of normal human melanocytes and malignant melanomas, caused extensive dendrite formation and severe disruption of cell-cell contact--morphological changes that were not observed upon inhibition of the genes encoding basic fibroblast growth factor (bFGF) and retinoic acid-alpha receptor. Thus, unlike in the case of the ligand bFGF, expression of the FGFR-1 may represent a requisite to prevent human melanocytes and malignant melanomas from undergoing (terminal) differentiation.

subject areas

  • Base Sequence
  • Cell Communication
  • Cell Differentiation
  • Cell Division
  • Gene Expression
  • Humans
  • Melanocytes
  • Melanoma
  • Molecular Sequence Data
  • Oligonucleotides, Antisense
  • RNA, Messenger
  • Receptors, Fibroblast Growth Factor
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Identity

International Standard Serial Number (ISSN)

  • 0950-9232

PubMed ID

  • 1437152
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Additional Document Info

start page

  • 2303

end page

  • 2313

volume

  • 7

issue

  • 11

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