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Hiv and hcmv coinfect brain-cells in patients with aids

Academic Article
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Overview

authors

  • Nelson, J. A.
  • Reynoldskohler, C.
  • Oldstone, Michael
  • Wiley, C. A.

publication date

  • July 1988

journal

  • Virology  Journal

abstract

  • Direct interactions at the cellular level in vitro have been reported which suggest that opportunistic viruses may reactivate latent human immunodeficiency virus (HIV) in cells. The significance of these findings depends on whether coinfection of the same cell with these two different types of viruses occurs in vivo. Using various double-labeling techniques, we present evidence that human cytomegalovirus (HCMV) and HIV can coinfect the same cell in vivo in central nervous system tissue from AIDS patients. These observations indicate that direct cooperation at the single cell level could occur between HCMV and HIV. This new finding in the context of reports that herpesviruses can increase HIV transcription in vitro, suggest the possibility of a direct role for herpesviruses in the pathogenesis of AIDS.

subject areas

  • Acquired Immunodeficiency Syndrome
  • Brain
  • Cytomegalovirus
  • Cytomegalovirus Infections
  • HIV
  • Humans
  • Virus Activation
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Identity

International Standard Serial Number (ISSN)

  • 0042-6822

Digital Object Identifier (DOI)

  • 10.1016/0042-6822(88)90685-x

PubMed ID

  • 2838967
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Additional Document Info

start page

  • 286

end page

  • 290

volume

  • 165

issue

  • 1

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