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Association of human cyclin-e with a periodic g(1)-s phase protein-kinase

Academic Article
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Overview

authors

  • Dulic, V.
  • Lees, E.
  • Reed, Steven

publication date

  • 1992

journal

  • Science  Journal

abstract

  • G1 cyclins control the G1 to S phase transition in the budding yeast, Saccharomyces cerevisiae. Cyclin E was discovered in the course of a screen for human complementary DNAs that rescue a deficiency of G1 cyclin function in budding yeast. The amounts of both the cyclin E protein and an associated protein kinase activity fluctuated periodically through the human cell cycle; both were maximal in late G1 and early S phases. Cyclin E-associated kinase activity was correlated with the appearance of complexes containing cyclin E and the cyclin-dependent kinase Cdk2. Thus, the cyclin E-Cdk2 complex may constitute a human G1-S phase-specific regulatory protein kinase.

subject areas

  • CDC2-CDC28 Kinases
  • Cell Cycle
  • Cyclin-Dependent Kinase 2
  • Cyclin-Dependent Kinases
  • Cyclins
  • HeLa Cells
  • Humans
  • Immunologic Techniques
  • Macromolecular Substances
  • Protamine Kinase
  • Protein Binding
  • Protein Kinases
  • Protein-Serine-Threonine Kinases
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Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.1329201

PubMed ID

  • 1329201
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Additional Document Info

start page

  • 1958

end page

  • 1961

volume

  • 257

issue

  • 5078

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