Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Serotonin receptor signaling and regulation via beta-arrestins

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Bohn, Laura
  • Schmid, C. L.

publication date

  • December 2010

journal

  • Critical Reviews in Biochemistry and Molecular Biology  Journal

abstract

  • Serotonin receptors are the product of 15 distinct genes, 14 of which are G protein-coupled receptors. These receptors are expressed in a wide range of cell types, including distinct neuronal populations, and promote diverse functional responses in multiple organ systems. These receptors are important for mediating the in vivo effects of their cognate neurotransmitter, serotonin, as well as the endogenous tryptamines. In addition, the actions of many drugs are mediated, either directly or indirectly, through serotonin receptors, including antidepressants, antipsychotics, anxiolytics, sleep aids, migraine therapies, gastrointestinal therapeutics and hallucinogenic drugs. It is becoming increasingly evident that serotonin receptors can engage in differential signaling that is determined by the chemical nature of the ligand and that ligands that demonstrate a predilection for inducing a particular signaling cascade are considered to have "functional selectivity". The elucidation of the cellular signaling pathways that mediate the physiological responses to serotonin and other agonists is an active area of investigation and will be an onward-looking focal point for determining how to effectively and selectively promote beneficial serotonergic mimicry while avoiding unwanted clinical side effects. This review highlights the modulation of serotonin 2A, 2C, and four receptors by β-arrestins, which may represent a fulcrum for biasing receptor responsiveness in vivo.

subject areas

  • Animals
  • Anti-Anxiety Agents
  • Antidepressive Agents
  • Antipsychotic Agents
  • Arrestins
  • Central Nervous System
  • Hallucinogens
  • Humans
  • Neurons
  • Peripheral Nervous System
  • Receptors, G-Protein-Coupled
  • Receptors, Serotonin
  • Serotonin
  • Serotonin Receptor Agonists
  • Signal Transduction
scroll to property group menus

Identity

PubMed Central ID

  • PMC4776633

International Standard Serial Number (ISSN)

  • 1040-9238

Digital Object Identifier (DOI)

  • 10.3109/10409238.2010.516741

PubMed ID

  • 20925600
scroll to property group menus

Additional Document Info

start page

  • 555

end page

  • 566

volume

  • 45

issue

  • 6

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support